Pyrazinamide plasma concentrations in young children with tuberculosis
Date
2011
Authors
McIlleron H.
Willemse M.
Schaaf H.S.
Smith P.J.
Donald P.R.
Journal Title
Journal ISSN
Volume Title
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Abstract
Pyrazinamide plasma concentrations were determined in 34 children (median age, 3.32 years) 1 month after commencing antituberculosis treatment. The median (interquartile range) peak concentration was 30.7 (25.5, 35.0) mg/L after a median dose of 23 mg/kg. Peak concentrations <20 mg/L were found in 5 children (15%) and such low concentrations were particularly likely after doses <20 mg/kg. © 2011 Lippincott Williams & Wilkins, Inc.
Description
Keywords
isoniazid, isoniazid plus pyrazinamide plus rifampicin, pyrazinamide, rifampicin, rimcure paed 3, unclassified drug, absence of side effects, area under the curve, article, child, clinical article, drug blood level, drug half life, human, infant, maximum plasma concentration, preschool child, priority journal, school child, tuberculosis
Citation
Pediatric Infectious Disease Journal
30
3
30
3