The role of epigenetic modifications for the pathogenesis of Crohn's disease
Date
2021-05-12
Journal Title
Journal ISSN
Volume Title
Publisher
BMC (part of Springer Nature)
Abstract
Epigenetics has become a promising field for finding new biomarkers and improving diagnosis, prognosis, and drug
response in inflammatory bowel disease. The number of people suffering from inflammatory bowel diseases, especially
Crohn’s disease, has increased remarkably. Crohn’s disease is assumed to be the result of a complex interplay
between genetic susceptibility, environmental factors, and altered intestinal microbiota, leading to dysregulation of
the innate and adaptive immune response. While many genetic variants have been identified to be associated with
Crohn’s disease, less is known about the influence of epigenetics in the pathogenesis of this disease. In this review,
we provide an overview of current epigenetic studies in Crohn’s disease. In particular, we enable a deeper insight into
applied bioanalytical and computational tools, as well as a comprehensive update toward the cell-specific evaluation
of DNA methylation and histone modifications.
Description
CITATION: Hornschuh, M., et al. 2021. The role of epigenetic modifications for the pathogenesis of Crohn's disease. Clinical Epigenetics, 13:108, doi:10.1186/s13148-021-01089-3.
The original publication is available at https://clinicalepigeneticsjournal.biomedcentral.com
The original publication is available at https://clinicalepigeneticsjournal.biomedcentral.com
Keywords
Crohn's disease -- Pathogenesis, Epigenetics, Digestive organs -- Diseases, Inflammatory bowel diseases -- Genetic aspects
Citation
Hornschuh, M., et al. 2021. The role of epigenetic modifications for the pathogenesis of Crohn's disease. Clinical Epigenetics, 13:108, doi:10.1186/s13148-021-01089-3