The role of epigenetic modifications for the pathogenesis of Crohn's disease

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dc.contributor.authorHornschuh, M.en_ZA
dc.contributor.authorWirthgen, E.en_ZA
dc.contributor.authorWolfien, M.en_ZA
dc.contributor.authorSingh, K. Pen_ZA
dc.contributor.authorWolkenhauer, O.en_ZA
dc.contributor.authorDabritz, J.en_ZA
dc.date.accessioned2021-08-19T06:35:00Z
dc.date.available2021-08-19T06:35:00Z
dc.date.issued2021-05-12
dc.date.updated2021-05-16T03:15:27Z
dc.descriptionCITATION: Hornschuh, M., et al. 2021. The role of epigenetic modifications for the pathogenesis of Crohn's disease. Clinical Epigenetics, 13:108, doi:10.1186/s13148-021-01089-3.
dc.descriptionThe original publication is available at https://clinicalepigeneticsjournal.biomedcentral.com
dc.description.abstractEpigenetics has become a promising field for finding new biomarkers and improving diagnosis, prognosis, and drug response in inflammatory bowel disease. The number of people suffering from inflammatory bowel diseases, especially Crohn’s disease, has increased remarkably. Crohn’s disease is assumed to be the result of a complex interplay between genetic susceptibility, environmental factors, and altered intestinal microbiota, leading to dysregulation of the innate and adaptive immune response. While many genetic variants have been identified to be associated with Crohn’s disease, less is known about the influence of epigenetics in the pathogenesis of this disease. In this review, we provide an overview of current epigenetic studies in Crohn’s disease. In particular, we enable a deeper insight into applied bioanalytical and computational tools, as well as a comprehensive update toward the cell-specific evaluation of DNA methylation and histone modifications.en_ZA
dc.description.urihttps://clinicalepigeneticsjournal.biomedcentral.com
dc.description.versionPublisher's version
dc.format.extent14 pages
dc.identifier.citationHornschuh, M., et al. 2021. The role of epigenetic modifications for the pathogenesis of Crohn's disease. Clinical Epigenetics, 13:108, doi:10.1186/s13148-021-01089-3
dc.identifier.issn1868-7083 (online)
dc.identifier.issn1868-7075 (print)
dc.identifier.otherdoi:10.1186/s13148-021-01089-3
dc.identifier.urihttp://hdl.handle.net/10019.1/110875
dc.language.isoen_ZAen_ZA
dc.publisherBMC (part of Springer Nature)
dc.rights.holderAuthors retain copyright
dc.subjectCrohn's disease -- Pathogenesisen_ZA
dc.subjectEpigeneticsen_ZA
dc.subjectDigestive organs -- Diseasesen_ZA
dc.subjectInflammatory bowel diseases -- Genetic aspectsen_ZA
dc.titleThe role of epigenetic modifications for the pathogenesis of Crohn's diseaseen_ZA
dc.typeArticle
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