Drug repurposing and optimisation to improve tuberculosis treatment

Abulfathi, Ahmed Aliyu (2021-03)

Thesis (PhD)--Stellenbosch University, 2021.

Thesis

ENGLISH ABSTRACT: Tuberculosis, a leading infectious cause of mortality, morbidity, and reduced quality of life with loss of income, remains a huge public health burden particularly in resource-limited settings. The golden thread throughout this dissertation, was improving tuberculosis treatment through repurposing and optimisation of existing medicines. For that purpose, we sought to improve our understanding of the pharmacokinetics and pharmacodynamics of selected anti-tuberculosis drugs.

AFRIKAANSE OPSOMMING: Tuberkulose, ‘n hoofoorsaak van infeksiesiekte mortaliteit, morbiditeit en verlaagte lewenskwaliteit met verlies aan inkomste, bly ‘n enorme publieke gesondheidslas, veral in omgewings met beperkte hulpbronne. Ons het met hierdie tesis deurlopend beoog om tuberkulose behandeling deur die heroormerking en optimisering van bestaande medisynes te verbeter. Ten einde hierdie doel te bereik, het ons dit ten doel gestel om ons begrip van die farmakokinetika en farmakodinamika van gekose teen-tuberkulose middels te bevorder.

Please refer to this item in SUNScholar by using the following persistent URL: http://hdl.handle.net/10019.1/110465
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