Drug repurposing and optimisation to improve tuberculosis treatment

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dc.contributor.advisorSvensson, Elin M.en_ZA
dc.contributor.advisorReuter, Helmuthen_ZA
dc.contributor.advisorDiacon, Andreas H.en_ZA
dc.contributor.authorAbulfathi, Ahmed Aliyuen_ZA
dc.contributor.otherStellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Medicine: Clinical Pharmacology.en_ZA
dc.date.accessioned2021-05-18T08:00:28Z
dc.date.available2021-05-18T08:00:28Z
dc.date.issued2021-03
dc.descriptionThesis (PhD)--Stellenbosch University, 2021.en_ZA
dc.description.abstractENGLISH ABSTRACT: Tuberculosis, a leading infectious cause of mortality, morbidity, and reduced quality of life with loss of income, remains a huge public health burden particularly in resource-limited settings. The golden thread throughout this dissertation, was improving tuberculosis treatment through repurposing and optimisation of existing medicines. For that purpose, we sought to improve our understanding of the pharmacokinetics and pharmacodynamics of selected anti-tuberculosis drugs.en_ZA
dc.description.abstractAFRIKAANSE OPSOMMING: Tuberkulose, ‘n hoofoorsaak van infeksiesiekte mortaliteit, morbiditeit en verlaagte lewenskwaliteit met verlies aan inkomste, bly ‘n enorme publieke gesondheidslas, veral in omgewings met beperkte hulpbronne. Ons het met hierdie tesis deurlopend beoog om tuberkulose behandeling deur die heroormerking en optimisering van bestaande medisynes te verbeter. Ten einde hierdie doel te bereik, het ons dit ten doel gestel om ons begrip van die farmakokinetika en farmakodinamika van gekose teen-tuberkulose middels te bevorder.en_ZA
dc.description.versionDoctoralen_ZA
dc.format.extent228 pagesen_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/110465
dc.language.isoen_ZAen_ZA
dc.publisherStellenbosch : Stellenbosch Universityen_ZA
dc.rights.holderStellenbosch Universityen_ZA
dc.subjectUCTDen_ZA
dc.subjectRifampicinen_ZA
dc.subjectTuberculosis -- Treatmenten_ZA
dc.subjectPharmacokineticsen_ZA
dc.subjectTuberculosis vaccinesen_ZA
dc.subjectPulmonary tuberculosisen_ZA
dc.titleDrug repurposing and optimisation to improve tuberculosis treatmenten_ZA
dc.typeThesisen_ZA
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Doctoral Degrees (Clinical Pharmacology)