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Context‐dependent costs and benefits of tuberculosis resistance traits in a wild mammalian host

dc.contributor.authorTavalire, Hannah F.en_ZA
dc.contributor.authorBeechler, Brianna R.en_ZA
dc.contributor.authorBuss, Peter E.en_ZA
dc.contributor.authorGorsich, Erin E.en_ZA
dc.contributor.authorHoal, Eileen G.en_ZA
dc.contributor.authorLe Roex, Nikkien_ZA
dc.contributor.authorSpaan, Johannie M.en_ZA
dc.contributor.authorSpaan, Robert S.en_ZA
dc.contributor.authorVan Helden, Paul D.en_ZA
dc.contributor.authorEzenwa, Vanessa O.en_ZA
dc.contributor.authorJolles, Anna E.en_ZA
dc.date.accessioned2020-01-31T07:46:15Z
dc.date.available2020-01-31T07:46:15Z
dc.date.issued2018
dc.identifier.citationTavalire, H. F., et al. 2018. Context‐dependent costs and benefits of tuberculosis resistance traits in a wild mammalian host. Ecology and Evolution, 8(24):12712-12726, doi:10.1002/ece3.4699
dc.identifier.issn2045-7758 (online)
dc.identifier.otherdoi:10.1002/ece3.4699
dc.identifier.urihttp://hdl.handle.net/10019.1/107404
dc.descriptionCITATION: Tavalire, H. F., et al. 2018. Context‐dependent costs and benefits of tuberculosis resistance traits in a wild mammalian host. Ecology and Evolution, 8(24):12712-12726, doi:10.1002/ece3.4699.
dc.descriptionThe original publication is available at https://onlinelibrary.wiley.com
dc.description.abstractDisease acts as a powerful driver of evolution in natural host populations, yet individuals in a population often vary in their susceptibility to infection. Energetic trade‐offs between immune and reproductive investment lead to the evolution of distinct life history strategies, driven by the relative fitness costs and benefits of resisting infection. However, examples quantifying the cost of resistance outside of the laboratory are rare. Here, we observe two distinct forms of resistance to bovine tuberculosis (bTB), an important zoonotic pathogen, in a free‐ranging African buffalo (Syncerus caffer) population. We characterize these phenotypes as “infection resistance,” in which hosts delay or prevent infection, and “proliferation resistance,” in which the host limits the spread of lesions caused by the pathogen after infection has occurred. We found weak evidence that infection resistance to bTB may be heritable in this buffalo population (h2 = 0.10) and comes at the cost of reduced body condition and marginally reduced survival once infected, but also associates with an overall higher reproductive rate. Infection‐resistant animals thus appear to follow a “fast” pace‐of‐life syndrome, in that they reproduce more quickly but die upon infection. In contrast, proliferation resistance had no apparent costs and was associated with measures of positive host health—such as having a higher body condition and reproductive rate. This study quantifies striking phenotypic variation in pathogen resistance and provides evidence for a link between life history variation and a disease resistance trait in a wild mammalian host population.en_ZA
dc.description.urihttps://onlinelibrary.wiley.com/doi/10.1002/ece3.4699
dc.format.extent15 pages
dc.language.isoen_ZAen_ZA
dc.publisherWiley Open Access
dc.subjectTuberculosisen_ZA
dc.subjectTuberculosis in animalsen_ZA
dc.subjectAfrican buffalo -- Disease resistanceen_ZA
dc.subjectAnimals as carriers of disease -- Analysisen_ZA
dc.subjectWildlife diseases -- Pathogensen_ZA
dc.subjectMammals -- Population viability analysisen_ZA
dc.subjectCoevolution -- Infectionsen_ZA
dc.subjectZoonoses -- Pathogensen_ZA
dc.titleContext‐dependent costs and benefits of tuberculosis resistance traits in a wild mammalian hosten_ZA
dc.typeArticleen_ZA
dc.description.versionPublisher's version
dc.rights.holderAuthors retain copyright


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