Research Articles (Obstetrics and Gynaecology)
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A case series of post-partum haemorrhage managed using Ellavi uterine balloon tamponade in a rural regional hospital
(AOSIS, 2021-05)Uterine balloon tamponade (UBT) should be attempted once emergency measures have been applied and medical treatment for post-partum haemorrhage (PPH) resulting from an atonic uterus has failed. Sinapi Biomedical (Pty) Ltd ... -
Using a composite maternal-infant outcome measure in tuberculosis prevention studies among pregnant women
(Oxford University Press, 2021-08-02)Background: Tuberculosis (TB-)-preventive therapy (TPT) among pregnant women reduces risk of TB in mothers and infants, but timing of initiation should consider potential adverse effects. We propose an analytical approach ... -
Pregnancy outcomes of women conceiving on antiretroviral therapy (ART) compared to those commenced on ART during pregnancy
(Oxford University Press, 2021-07)Background: Globally, the number of infected women of childbearing age living with human immunodeficiency virus (HIV) and conceiving on antiretroviral therapy (ART) is increasing. Evidence of ART safety at conception and ... -
Individual and composite adverse pregnancy outcomes in a randomized trial on isoniazid preventative therapy among women living with human immunodeficiency virus
(Oxford University Press, 2021-06-01)Background: International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) P1078, a randomized noninferiority study designed to compare the safety of starting isoniazid preventive therapy (IPT) in women living ... -
Effects of pregnancy and isoniazid preventive therapy on mycobacterium tuberculosis interferon gamma response assays in women with HIV
(Oxford University Press, 2020-07)Background Pregnancy is accompanied by immune suppression. We hypothesized that Mycobacterium tuberculosis-specific inflammatory responses used to identify latent tuberculosis infection (LTBI) lose positivity during ... -
Transitional objects of grief
(Comprensive Psychiatry, 2020-01)Background: Transitional objects provide security and symbolic connection with valued others when separated from them. Bereaved parents often keep, cherish and visit saved objects of their deceased child. This research ... -
Additional value of advanced neurosonography and magnetic resonance imaging in fetuses at risk for brain damage
(John Wiley & Sons, 2020)Objective: To assess the additional value of fetal multiplanar (axial, coronal and sagittal) neurosonography and magnetic resonance imaging (MRI) to that of the standard axial ultrasound planes in diagnosing brain damage ... -
INTERGROWTH-21st v. local South African growth standards (Theron-Thompson) for identification of small-for-gestational-age fetuses in stillbirths : a closer look at variation across pregnancy
(Health & Medical Publishing Group, 2019)Background. Global growth standards for fetuses were recently developed (INTERGROWTH-21st). It has been advocated that professional bodies should adopt these global standards. Objectives. To compare the ability of ... -
Evidence of neuroinflammation and blood–brain barrier disruption in women with preeclampsia and eclampsia
(MDPI, 2021-11-05)ENGLISH ABSTRACT: Cerebral complications in preeclampsia are leading causes of maternal mortality. Animal models suggest that an injured blood–brain barrier and neuroinflammation may be important but there is paucity of ... -
Neural tube defect diagnosis and outcomes at a tertiary South African hospital with intensive case ascertainment
(Health & Medical Publishing Group, 2019)Background. Neural tube defects (NTDs) are an important category of birth defect, but surveillance remains inadequate in South Africa. Objectives. To assess the identification of NTDs at a tertiary hospital using a range ... -
Slow acceptance of universal antiretroviral therapy (ART) among mothers enrolled in IMPAACT PROMISE studies across the globe
(Springer, 2019)ENGLISH ABSTRACT: The PROMISE trial enrolled asymptomatic HIV-infected pregnant and postpartum women not eligible for antiretroviral treatment (ART) per local guidelines and randomly assigned proven antiretroviral strategies ... -
Bone involvement in patients with cervical carcinoma : a single-institution cohort study
(Taylor & Francis, 2019-12-13)Introduction: Bony metastases in cervical carcinoma are rare; however, autopsy studies indicate that they are underdiagnosed. A retrospective study was undertaken to describe the risk factors and tumour characteristics and ... -
Stillbirth risk across pregnancy by size for gestational age in Western Cape Province, South Africa : application of the fetuses-at-risk approach using perinatal audit data
(South African Medical Association, 2019-11-27)Background: There is little published work on the risk of stillbirth across pregnancy for small-for-gestational-age (SGA) and large-for-gestational (LGA) pregnancies in low-resource settings. Objectives: To compare ... -
Pregnancy-related acute kidney injury in preeclampsia : risk factors and renal outcomes
(American Heart Association, 2019)ENGLISH ABSTRACT: Preeclampsia is a common cause of acute kidney injury (AKI) in low- and middle-income countries, but AKI incidence in preeclampsia, its risk factors, and renal outcomes are unknown. A prospective ... -
The efficacy of intrauterine devices for emergency contraception and beyond : a systematic review update
(Dove Medical Press, 2019)Background: The copper intrauterine device (IUD) is a very effective form of emergency contraception. The failure rate is about 0.1%. IUDs are also very cost-effective when used as long acting-reversible contraception ... -
Prepregnancy and early pregnancy calcium supplementation among women at high risk of pre-eclampsia : a multicentre, double-blind, randomised, placebo-controlled trial
(Elsevier, 2019)Background: Reducing deaths from hypertensive disorders of pregnancy is a global priority. Low dietary calcium might account for the high prevalence of pre-eclampsia and eclampsia in low-income countries. Calcium supplementation ... -
Should home-based ovulation predictor kits be offered as an additional approach for fertility management for women and couples desiring pregnancy? a systematic review and meta-analysis
(BMJ Publishing Group, 2019)ENGLISH ABSTRACT: Introduction to inform the WHO Guideline on self-care interventions, we conducted a systematic review of the impact of ovulation predictor kits (OPKs) on time-topregnancy, pregnancy, live birth, ... -
Delivery outcomes of patients with pre-eclampsia at 27 - 34 weeks’ gestation at Tygerberg Hospital, Cape Town, South Africa : a retrospective observational study
(Health & Medical Publishing Group, 2021-04-03)Background. Obstetricians are cognisant of the serious nature of hypertensive disorders in pregnancy. Despite a 17% overall reduction in maternal deaths in South Africa between 2011 and 2016, there was a 14% increase in ... -
Shock index thresholds to predict adverse outcomes in maternal hemorrhage and sepsis : a prospective cohort study
(Wiley, 2019)Introduction: Shock index (SI) is a predictor of hemodynamic compromise in obstetric patients. The SI threshold for action is not well understood. We aimed to evaluate SI thresholds as predictors of outcomes in obstetric ... -
Maternal and perinatal adverse outcomes in women with pre-eclampsia cared for at facility-level in South Africa : a prospective cohort study
(Edinburgh University Global Health Society, 2018)Background: Hypertensive disorders of pregnancy contribute to 14% of all maternal deaths, the majority of which occur in low- and middle-income countries. The aim of the study was to describe the maternal and perinatal clinical ...
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