Cardiac glucolipotoxicity and cardiovascular outcomes
Date
2018
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Abstract
Cardiac insulin signaling can be impaired due to the altered fatty acid metabolism to induce insulin resistance. In diabetes and insulin resistance, the metabolic, structural and ultimately functional alterations in the heart and vasculature culminate in diabetic cardiomyopathy, coronary artery disease, ischemia and eventually heart failure. Glucolipotoxicity describes the combined, often synergistic, adverse effects of elevated glucose and free fatty acid concentrations on heart structure, function, and survival. The quality of fatty acid shapes the cardiac structure and function, often influencing survival. A healthy fatty acid balance is therefore critical for maintaining cardiac integrity and function.
Description
CITATION: Cerf, M. E. 2018. Cardiac glucolipotoxicity and cardiovascular outcomes. Medicina, 54(5):70, doi:10.3390/medicina54050070.
The original publication is available at https://www.mdpi.com
The original publication is available at https://www.mdpi.com
Keywords
Bioenergetics, Cardiac glycosides, Hyperglycemia, Fatty acids
Citation
Cerf, M. E. 2018. Cardiac glucolipotoxicity and cardiovascular outcomes. Medicina, 54(5):70, doi:10.3390/medicina54050070