Cardiac glucolipotoxicity and cardiovascular outcomes

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dc.contributor.authorCerf, Marlon E.en_ZA
dc.date.accessioned2019-10-17T10:16:46Z
dc.date.available2019-10-17T10:16:46Z
dc.date.issued2018
dc.descriptionCITATION: Cerf, M. E. 2018. Cardiac glucolipotoxicity and cardiovascular outcomes. Medicina, 54(5):70, doi:10.3390/medicina54050070.
dc.descriptionThe original publication is available at https://www.mdpi.com
dc.description.abstractCardiac insulin signaling can be impaired due to the altered fatty acid metabolism to induce insulin resistance. In diabetes and insulin resistance, the metabolic, structural and ultimately functional alterations in the heart and vasculature culminate in diabetic cardiomyopathy, coronary artery disease, ischemia and eventually heart failure. Glucolipotoxicity describes the combined, often synergistic, adverse effects of elevated glucose and free fatty acid concentrations on heart structure, function, and survival. The quality of fatty acid shapes the cardiac structure and function, often influencing survival. A healthy fatty acid balance is therefore critical for maintaining cardiac integrity and function.en_ZA
dc.description.urihttps://www.mdpi.com/1010-660X/54/5/70
dc.description.versionPublisher's version
dc.format.extent15 pagesen_ZA
dc.identifier.citationCerf, M. E. 2018. Cardiac glucolipotoxicity and cardiovascular outcomes. Medicina, 54(5):70, doi:10.3390/medicina54050070
dc.identifier.issn1010-660X (online)
dc.identifier.otherdoi:10.3390/medicina54050070
dc.identifier.urihttp://hdl.handle.net/10019.1/106660
dc.language.isoen_ZAen_ZA
dc.publisherMDPIen_ZA
dc.rights.holderAuthor retains copyrighten_ZA
dc.subjectBioenergeticsen_ZA
dc.subjectCardiac glycosidesen_ZA
dc.subjectHyperglycemiaen_ZA
dc.subjectFatty acidsen_ZA
dc.titleCardiac glucolipotoxicity and cardiovascular outcomesen_ZA
dc.typeArticleen_ZA
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