Research Articles (Paediatrics and Child Health)
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Bacille Calmette-Guerin (BCG) vaccine and the COVID-19 pandemic : responsible stewardship is needed
(The Union, 2020)We believe that responsible stewardship of the bacille Calmette-Guérin (BCG) vaccine in the context of the COVID-19 epidemic is urgently needed. Live attenuated BCG is currently the only licensed vaccine to protect against ... -
South African healthcare workers and COVID-19 : a shared responsibility to protect a precious and limited resource
(Health & Medical Publishing Group, 2020)Healthcare workers (HCWs) in African countries face high risks of occupational exposure to many pathogens, including tuberculosis, measles, HIV and Ebola.[1,2] The novel coronavirus SARSCoV- 2 poses an arguably greater ... -
Burkitt lymphoma – nutritional support during induction treatment : effect on anthropometric parameters and morbidity of treatment
(AOSIS, 2018-10-22)Background: Malnutrition is common in children diagnosed with cancer in Africa, and it adds to the morbidity and mortality of treatment. Nutritional support is known to reduce morbidity and mortality of treatment. Aim: ... -
Personal protective equipment (PPE) in a pandemic : approaches to PPE preservation for South African healthcare facilities
(Health & Medical Publishing Group, 2020-04-30)Personal protective equipment (PPE) is key to protecting healthcare workers from COVID-19 infection, but the pandemic has disrupted supply chains globally and necessitated rapid review of the scientific evidence for PPE ... -
Five year neurodevelopment outcomes of perinatally HIV-infected children on early limited or deferred continuous antiretroviral therapy
(Wiley Open Access, 2018)Introduction: Early antiretroviral therapy (ART) has improved neurodevelopmental outcomes of HIV-infected (HIV-positive) children; however, little is known about the longer term outcomes in infants commencing early ART ... -
Pediatric Xanthogranulomatus cholangitis
(Elsevier, 2018)ENGLISH ABSTRACT: The Xanthogranulomatous cholangitis is rare entity, usually it happens as an extension of Xanthogranuloma of the gall bladder (XCC) [1], although they are case reports of isolated Xanthogranulomatous ... -
Early childhood caries and dental treatment need in low socio-economic communities in Cape Town, South Africa
(AOSIS, 2018-05-12)Background: Early childhood caries (ECC) is a particularly severe problem in low socio-economic communities which impacts the overall health and well-being of children. The extensive waiting lists for general anaesthesia ... -
Comparison of the demographic and diagnostic profile of new patients attending a neurodevelopmental clinic in 2008/2009 and 2016
(Health & Medical Publishing Group, 2019-04)Background. Literature suggests an increasing prevalence of developmental disabilities, and specifically of conditions such as autism and attention deficit/hyperactivity disorder. The resulting burden on paediatric ... -
Neurodevelopment at 11 months after starting antiretroviral therapy within 3 weeks of life
(AOSIS, 2019-10-03)Background: Antiretroviral therapy (ART) started between 7 and 12 weeks of age improves neurodevelopmental outcomes in HIV-infected (HIV+) infants, but the impact of even earlier initiation is not yet described. Objectives: ... -
Current perspectives on paediatric HIV management from the Mexico International Aids Society Conference, 2019
(AOSIS, 2019-10-31)ENGLISH ABSTRACT: While acknowledging the great achievements in getting 23 million people living with HIV to access antiretroviral treatment (ART) globally, there is still more to do in order to close the HIV treatment ... -
The peripartum management of a 32-year-old patient presenting at 34 weeks’ gestation with unrepaired cyanotic heart disease
(Health and Medical Publishing Group, 2018-11)ENGLISH ABSTRACT: Unrepaired cyanotic heart disease is considered a high-risk lesion owing to the consequent increase in maternal and fetal complications. In the presence of pulmonary hypertension, maternal mortality ... -
The impact of cerebrospinal fluid viral analysis on empiric antibiotic use in children admitted to Tygerberg Children’s hospital with suspected meningitis
(Medpharm Publications, 2018)Background: Viral meningitis is the most common form of aseptic meningitis and requires minimal investigation and treatment. Polymerase chain reaction (PCR) has become the ‘gold standard’ for identifying viruses in ... -
HIV-1 RNA testing of pooled dried blood spots is feasible to diagnose acute HIV infection in resource limited settings
(Medpharm Publications, 2018)Objectives: Rapid human immunodeficiency virus (HIV) antibody tests, routinely used for diagnosis in adults and older children in resource-limited settings (RLS), do not detect early HIV infections prior to seroconversion ... -
Tonsillar hypertrophy and prolapse in a child – is epiglottitis a predisposing factor for sudden unexpected death?
(BMC (part of Springer Nature), 2020-01-20)Background: Tonsillitis, with associated tonsillar hypertrophy, is a common disease of childhood, yet it is rarely associated with sudden death due to airway obstruction. Lethal complications involving the inflamed ... -
Bacterial pathogens and resistance causing community acquired paediatric bloodstream infections in low- and middle-income countries : a systematic review and meta-analysis
(BMC (part of Springer Nature), 2019-12-30)Background: Despite a high mortality rate in childhood, there is limited evidence on the causes and outcomes of paediatric bloodstream infections from low- and middle-income countries (LMICs). We conducted a systematic review ... -
Burkitt's lymphoma : the prevalence of HIV/AIDS and the outcome of treatment
(Health & Medical Publishing Group, 2018)The prevalence of HIV in Burkitt’s lymphoma (BL) patients and the outcome of treatment in Cameroon were unknown. Records of all patients diagnosed with BL at three Cameroon Baptist Convention hospitals were reviewed to ... -
Healthcare-associated infections in paediatric and neonatal wards : a point prevalence survey at four South African hospitals
(Health & Medical Publishing Group, 2018)Background. Healthcare-associated infections (HAIs) cause substantial morbidity, mortality and healthcare costs. The prevalence of neonatal/paediatric HAI at South African (SA) district and regional hospitals is ... -
Asthma treatment in children : a pragmatic approach
(Health & Medical Publishing Group, 2018)Background. Asthma is a heterogeneous condition characterised by chronic inflammation and variable expiratory airflow limitation, with airway reversibility. Management of chronic inflammation with anti-asthma medication ... -
Is adrenal suppression in asthmatic children reversible? A case series
(Health & Medical Publishing Group, 2018-06)Background. Six hypocortisolaemic asthmatic children on steroids given at physiological doses were identified during a previous study. Objectives. To establish whether hypothalamic-pituitary-adrenal axis suppression ... -
Neonatal and paediatric bloodstream infections : pathogens, antimicrobial resistance patterns and prescribing practice at Khayelitsha District Hospital, Cape Town, South Africa
(Health & Medical Publishing Group, 2018)Background. The epidemiology of neonatal and paediatric community-acquired and healthcare-associated bloodstream infections (BSI) at South African (SA) district hospitals is under-researched. Objective. Retrospective ...
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