Browsing by Author "Smith, R. M. L."

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    Cerebral oedema with coning in diabetic keto-acidosis : report of 2 survivors
    (Health & Medical Publishing Group, 1991) Kalis, N. N.; Van der Merwe, P.-L.; Schoeman, J. F.; Smith, R. M. L.
    Two children presented with a first episode of diabetic keto-acidosis. Initially both patients made a good clinical and biochemical recovery, but suddenly developed neurological signs consistent with a diagnosis of tentorial herniation. Cranial computed tomography showed signs of cerebral oedema in both cases with evidence of uncal and tentorial herniation in 1 patient, which resolved after the appropriate treatment. The excellent neurological outcome emphasises the need for early recognition and treatment of sudden onset brain oedema in diabetic keto-acidosis.
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    Holoprosencephaly : the use of magnetic resonance imaging and application in antenatal diagnosis
    (Health & Medical Publishing Group, 1993) Kolovos, I. G.; Smith, R. M. L.
    Holoprosencephaly is the result of disordered organogenesis within the central nervous system where the forebrain fails to undergo diverticulation and development between rhe 4th and 8rh week of fetal life.' It is associated with facial abnormalities. It is a rare condition (1:5200 to 1:16000 live births), usually diagnosed by antenatal ultrasound scanning.' This, however, represents 16% or more of all cases of fetal hydrocephalus detected.' In view of the serious nature of this condition, recognition of its morphological appearance on ultrasound examination is important to direct further management and patient counselling.