Browsing by Author "Sakkas, G. K."

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    Effects of redox disturbances on motility, contractility and muscle tissue pathogenesis
    (Hindawi, 2019-06-16) Karatzaferi, C.; Sandri, M.; Sakkas, G. K.; Smith, C.
    Whether in health or disease, reactive oxygen and nitrogen species (ROS/RNS) affect smooth and striated muscle status and function in ways not always discernible or appreciated. Despite the technological and methodological advancements, some key challenges still exist. On the one hand, one challenge is to appreciate acute effects on contractility and/or bioenergetics within a realistic functional context, effectively linking in vitro observations to in vivo conditions. On the other hand, chronic effects on indices of clinical significance are more difficult to clarify given the interplay of redox status variations with systemic inflammation and autophagy but also with lifestyle factors such as nutrition and physical activity—which impact on systemic health indices, as well as directly on smooth and striated muscles.