Effects of redox disturbances on motility, contractility and muscle tissue pathogenesis
Date
2019-06-16
Journal Title
Journal ISSN
Volume Title
Publisher
Hindawi
Abstract
Whether in health or disease, reactive oxygen and nitrogen
species (ROS/RNS) affect smooth and striated muscle status
and function in ways not always discernible or appreciated.
Despite the technological and methodological advancements,
some key challenges still exist. On the one hand, one challenge
is to appreciate acute effects on contractility and/or bioenergetics
within a realistic functional context, effectively
linking in vitro observations to in vivo conditions. On the
other hand, chronic effects on indices of clinical significance
are more difficult to clarify given the interplay of redox status
variations with systemic inflammation and autophagy but
also with lifestyle factors such as nutrition and physical
activity—which impact on systemic health indices, as well
as directly on smooth and striated muscles.
Description
CITATION: Karatzaferi, C. et al. 2019. Effects of redox disturbances on motility, contractility and muscle tissue pathogenesis. Oxidative Medicine and Cellular Longevity, 3272035, doi:10.1155/2019/3272035.
The original publication is available at https://www.hindawi.com
The original publication is available at https://www.hindawi.com
Keywords
Redox, Redox imbalance, Muscle cells -- Analysis, Pathogenesis
Citation
Karatzaferi, C. et al. 2019. Effects of redox disturbances on motility, contractility and muscle tissue pathogenesis. Oxidative Medicine and Cellular Longevity, 3272035, doi:10.1155/2019/3272035.