Browsing by Author "Kolovos, I. G."

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    Holoprosencephaly : the use of magnetic resonance imaging and application in antenatal diagnosis
    (Health & Medical Publishing Group, 1993) Kolovos, I. G.; Smith, R. M. L.
    Holoprosencephaly is the result of disordered organogenesis within the central nervous system where the forebrain fails to undergo diverticulation and development between rhe 4th and 8rh week of fetal life.' It is associated with facial abnormalities. It is a rare condition (1:5200 to 1:16000 live births), usually diagnosed by antenatal ultrasound scanning.' This, however, represents 16% or more of all cases of fetal hydrocephalus detected.' In view of the serious nature of this condition, recognition of its morphological appearance on ultrasound examination is important to direct further management and patient counselling.