Browsing by Author "De, Kock Carmen"
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- ItemSynthesis of triazole-linked 2-trichloromethylquinazolines and exploration of their efficacy against P. falciparum(University of KwaZulu-Natal, 2013) Hamann, Anton R.; De, Kock Carmen; Smith, Peter J.; Van Otterlo, Willem A. L.; Blackie, Margaret A. L.Using 2-trichloromethylquinazoline as scaffold, seven novel triazole-linked compounds have been synthesized using CuAAC chemistry. The in vitro biological activity of four of the compounds on the Plasmodium falciparum chloroquine-sensitive strain NF54 was then determined. The compounds which were tested showed moderate activity with 1.45 μM as the lowest inhibitory concentration.