Synthesis of triazole-linked 2-trichloromethylquinazolines and exploration of their efficacy against P. falciparum
Date
2013
Journal Title
Journal ISSN
Volume Title
Publisher
University of KwaZulu-Natal
Abstract
Using 2-trichloromethylquinazoline as scaffold, seven novel triazole-linked compounds have been synthesized using CuAAC
chemistry. The in vitro biological activity of four of the compounds on the Plasmodium falciparum chloroquine-sensitive strain
NF54 was then determined. The compounds which were tested showed moderate activity with 1.45 μM as the lowest inhibitory
concentration.
Description
CITATION: Hamann, A. R. et al. 2013. Synthesis of triazole-linked 2-trichloromethylquinazolines and exploration of their efficacy against P. falciparum. South African Journal of Chemistry, 66:231-236.
The original publication is available at http://www.scielo.org.za
The original publication is available at http://www.scielo.org.za
Keywords
Plasmodium falciparum
Citation
South African Journal of Chemistry-Suid-Afrikaanse Tydskrif Vir Chemie
Hamann, A. R. et al. 2013. Synthesis of triazole-linked 2-trichloromethylquinazolines and exploration of their efficacy against P. falciparum. South African Journal of Chemistry, 66:231-236.
Hamann, A. R. et al. 2013. Synthesis of triazole-linked 2-trichloromethylquinazolines and exploration of their efficacy against P. falciparum. South African Journal of Chemistry, 66:231-236.