Browsing by Author "Burger, B. F."

Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    Biological effect of asbestos dust on the peritoneal viscera of rats
    (Health & Medical Publishing Group, 1973-09) Engelbrecht, F. M.; Burger, B. F.
    ENGLISH ABSTRACT: Crocidolite and chrysotile asbestos suspensions were ip injected into rats. Peritoneal mesotheliomas were induced in 90% of the crocidolite group and in 30% of the chrysotile group. The pathology and possible pathogenesis are described and discussed. It is postulated that the asbestos fibers are encapsulated by fibrous tissue and that a soluble carcinogen then diffuses from these fibers to the mesothelial cells, causing anaplastic changes.
  • Thumbnail Image
    Item
    Mesothelial reaction to asbestos and other irritants after intraperitoneal injection
    (Health and Medical Publishing Group (HMPG), 1975) Engelbrecht, F. M.; Burger, B. F.
    Ten groups of rats were injected intraperitoneally with one of the following suspensions; standard reference crocidolite; acid treated crocidolite; crocidolite + iron oxide; crocidolite + silica; iron oxide; silica; long fiber crocidolite; short fiber crocidolite; long fiber glass and short fiber glass. Two rats from each group were killed at 45, 90, 150, 240 and 330 days respectively, and the pathology induced by the different suspensions was studied histologically at each time interval. No evidence in support of the chemical induction theory of mechanical irritation theory in the pathogenesis of peritoneal mesotheliomas could be found, although all the suspensions except iron oxide caused a reactive mesothelium.