50 years of Emmonsia disease in humans : the dramatic emergence of a cluster of novel fungal pathogens
CITATION: Schwartz, I. S. et al. 2015. 50 years of Emmonsia disease in humans : the dramatic emergence of a cluster of novel fungal pathogens. PLoS Pathogens, 11(11): e1005198, doi:10.1371/journal.ppat.1005198.
The original publication is available at http://journals.plos.org/plospathogens
New species of Emmonsia-like fungi, with phylogenetic and clinical similarities to Blastomyces and Histoplasma, have emerged as causes of systemic human mycoses worldwide. They differ from classical Emmonsia species by producing a thermally-dependent, yeast-like phase rather than adiaspores, and by causing disseminated infections, predominantly in immunocompromised patients and often with high case-fatality rates. Such differences will be important for clinicians to consider in diagnosis and patient management, and for microbiologists who may encounter these fungi with increasing frequency.