Pulmonology

Recent Submissions

  • Epidemiology of lower respiratory infection and pneumonia in South Africa (1997 – 2015) : a systematic review protocol 

    Roomaney, Rifqah A.; Pillay-van Wyk, Victoria; Awotiwon, Oluwatoyin F.; Dhansay, Ali; Groenewald, Pam; Joubert, Jane D.; Nglazi, Mweete D.; Nicol, Edward; Bradshaw, Debbie (BMJ Publishing Group, 2016)
    Introduction: Lower respiratory infections (LRIs) and pneumonia are among the leading causes of death worldwide, especially in children aged under 5 years, and these patterns are reflected in the South African population. ...

  • The impact of an electronic clinical decision support for pulmonary embolism imaging on the efficiency of computed tomography pulmonary angiography utilisation in a resource-limited setting 

    Murthy, C.; Davis, R.; Koegelenberg, C. F. N.; Irusen, E. M.; Pitcher, R. D. (Health & Medical Publishing Group, 2016-01)
    ENGLISH SUMMARY : Background. Pulmonary embolism (PE) is associated with high morbidity and mortality. Effective intervention requires prompt diagnosis. Computed tomography pulmonary angiography (CTPA) is sensitive and ...

  • The diagnostic accuracy of integrated positron emission tomography/computed tomography in the evaluation of pulmonary mass lesions in a tuberculosis-endemic area 

    Du Toit, R.; Shaw, J. A.; Irusen, E. M.; Von Groote-Bidlingmaier, F.; Warwick, J. M.; Koegelenberg, C. F. N. (Health and Medical Publishing Group, 2015)
    Background. Integrated positron emission tomography/computed tomography (PET-CT) is a well-validated modality for assessing pulmonary mass lesions and specifically for estimating risk of malignancy. Tuberculosis (TB) ...

  • The real value of endobronchial ultrasound 

    Vorster, Morne Johan; Schubert, Pawel Tomasz; Koegelenberg, Coenraad Frederik Nicolaas (Health and Medical Publishing Group, 2015)
    Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has become a standard procedure worldwide, used in conjunction with bronchoscopy to obtain biopsies for mediastinal disorders. A 67-year-old man ...

  • Recommendations for the use of bronchial thermoplasty in the management of severe asthma 

    Dheda, Keertan; Koegelenberg, Coenraad F. N.; Esmail, Aliasgar; Irusen, Elvis; Wechsler, Michael; Niven, Rob M.; Bateman, Eric D.; Chung, Kian Fan (Health & Medical Publishing Group, 2015)
    There are approximately 3 million asthma suffers in South Africa, and the national death rate is ranked as one of the highest in the world. Approximately 5% have severe asthma (uncontrolled despite being adherent on maximal ...

  • Pathogenesis of chronic obstructive pulmonary disease : an African perspective 

    Allwood, Brian; Calligaro, G . (Health & Medical Publishing Group, 2015)
    The importance of chronic obstructive pulmonary disease (COPD) as a global health problem cannot be overstated. According to the latest World Health Organization statistics (2005), 210 million people suffer from COPD ...

  • Lung volume reduction in chronic obstructive pulmonary disease 

    Vorster, M. J.; Koegelenberg, C. F. N. (Health & Medical Publishing Group, 2015)
    Pathognomonic features of advanced emphysema include a markedly reduced alveolar surface area due to the formation of blebs and bullae and significantly reduced elastic recoil. The aim of lung volume reduction, which can ...

  • Indications for the use of bronchial thermoplasty in severe asthma 

    Dheda, Keertan; Koegelenberg, Coenraad F. N.; Esmail, Aliasgar; Irusen, Elvis; Wechsler, Michael; Niven, Rob M.; Chung, Kian Fan; Bateman, Eric D. (Health & Medical Publishing Group, 2015)
    Approximately 5% of the ~3 million asthmatics in South Africa have severe asthma that is associated with substantial morbidity, cost, absenteeism, preventable mortality, and the requirement for costly chronic medication ...

  • Endoscopic lung volume reduction in severe emphysema 

    Koegelenberg, Coenraad Frederik N.; Theron, Johan; Bruwer, J. W.; Allwood, Brian W.; Vorster, Morne J.; Von Groote-Bidlingmaier, Florian; Dheda, Keertan (Health & Medical Publishing Group, 2015)
    ENGLISH ABSTRACT: Therapeutic options in severe emphysema are limited. Endoscopic lung volume reduction (ELVR) refers to bronchoscopically inducing volume loss to improve pulmonary mechanics and compliance, thereby reducing ...

  • Chronic obstructive pulmonary disease in South Africa : under-recognised and undertreated 

    Allwood, Brian; Van Zyl-Smit, Richard N. (Health & Medical Publishing Group, 2015)
    Chronic obstructive pulmonary disease (COPD) is a common, preventable but incurable condition currently ranked third in global mortality estimates. Worldwide, 65 million people are estimated to have moderate to severe ...

  • Validation of a severity-of-illness score in patients with tuberculosis requiring intensive care unit admission 

    Koegelenberg, Coenraad Frederik N.; Balkema, Cecile A.; Jooste, Ynishia; Taljaard, Jantjie J.; Irusen, Elvis M. (Health & Medical Publication Group, 2015-05-27)
    Background. There is a paucity of data on the determinants of mortality due to tuberculosis (TB) in the intensive care unit (ICU). Objective. To develop a simple severity-of-illness score for use in patients with TB admitted ...

  • Adenocarcinoma the most common cell type in patients presenting with primary lung cancer in the Western Cape 

    Koegelenberg, Coenraad F. N.; Aubeelack, Kushroo; Nanguzgambo, Aldoph B.; Irusen, Elvis M.; Mowlana, Abdurasiet; Von Groote-Bidlingmaier, Florian; Bolliger, Chris T. (Health and Medical Publishing Group (HMPG), 2011-05)
    Lung cancer is the most common cause of cancer-related mortality worldwide for men and women, causing approximately 1.2 million deaths per year. The absolute and relative frequencies of lung cancer have risen dramatically ...

  • The pharmacokinetics of enteral antituberculosis drugs in patients requiring intensive care 

    Koegelenberg, C. F. N.; Nortje, A.; Lalla, U.; Enslin, A.; Irusen, E. M.; Rosenkranz, B.; Seifart, H. I.; Bolliger, C. T. (Health and Medical Publishing Group (HMPG), 2013-06)
    Background. There is a paucity of data on the pharmacokinetics of fixed-dose combination enteral antituberculosis treatment in critically ill patients. Objectives. To establish the pharmacokinetic profile of a fixed-dose ...

  • The non-pharmacological management of COPD is a neglected area in the treatment of respiratory diseases 

    Irusen, E. M.; Plekker, D. (Health and Medical Publishing Group (HMPG), 2009-04)
    An almost uniformly neglected area of respiratory disease management is the non-pharmacological component. Most patients with chronic respiratory illnesses will lose their exercise capacity (deconditioning) as the illness ...

  • Asthma control 

    Irusen, E. M. (Continuing Medical Education, 2008-04)
    The SA Thoracic Society and the Global Initiative for Asthma (GINA) have recently published updated guidelines to assist practitioners in the management of asthma. The guidelines were based on reports that asthma ...

  • Tricyclic antidepressant overdose necessitating ICU admission 

    Koegelenberg, Coenraad F. N.; Joubert, Zirkia J.; Irusen, Elvis M. (Health and Medical Publishing Group (HMPG), 2012-05)
    Tricyclic antidepressant (TCA) overdose necessitating intensive care unit (ICU) admission remains a significant problem in the Western Cape. In this retrospective study, we reviewed the course of life-threatening TCA ...

  • Guideline for office spirometry in adults, 2004 

    Van Schalkwyk, E. M.; Schultz, C.; Joubert, J. R.; White, N. W. (Health & Medical Publishing Group, 2004-07)
    Objective. To provide clinical guidelines for office spirometry in South Africa. Options. More stringent guidelines are required for diagnostic laboratories and research. Outcomes. To minimise variations in standard practice ...