Recent Submissions

  • Differential inhibition of adenylylated and deadenylylated forms of M. tuberculosis glutamine synthetase as a drug discovery platform 

    Theron, A.; Roth, R. L.; Hoppe, H.; Parkinson, C.; Van Der Westhuyzen, C. W.; Stoychev, S.; Wiid, I.; Pietersen, R. D.; Baker, B.; Kenyon, C. P. (Public Library of Science, 2017-03-29)
    ENGLISH ABSTRACT: Glutamine synthetase is a ubiquitous central enzyme in nitrogen metabolism that is controlled by up to four regulatory mechanisms, including adenylylation of some or all of the twelve subunits by adenylyl ...
  • Detection of a combination of serum IgG and IgA antibodies against selected mycobacterial targets provides promising diagnostic signatures for active TB 

    Awoniyi, Dolapo O.; Baumann, Ralf; Chegou, Novel N.; Kriel, Belinda; Jacobs, Ruschca; Kidd, Martin; Loxton, Andre G.; Kaempfer, Susanne; Singh, Mahavir; Walzl, Gerhard (Impact Journals, 2017-03-24)
    ENGLISH ABSTRACT: Immunoglobulin G (IgG) based tests for the diagnosis of active tuberculosis (TB) disease often show a lack of specificity in TB endemic regions, which is mainly due to a high background prevalence of ...
  • Whole-genome sequencing for an enhanced understanding of genetic variation among South Africans 

    Choudhury, Ananyo; Ramsay, Michele; Hazelhurst, Scott; Aron, Shaun; Bardien, Soraya; Botha, Gerrit; Chimusa, Emile R.; Christoffels, Alan; Gamieldien, Junaid; Sefid-Dashti, Mahjoubeh J.; Joubert, Fourie; Meintjes, Ayton; Mulder, Nicola; Ramesar, Raj; Rees, Jasper; Scholtz, Kathrine; Sengupta, Dhriti; Soodyall, Himla; Venter, Philip; Warnich, Louise; Pepper, Michael S. (Nature Research (part of Springer Nature), 2017)
    ENGLISH ABSTRACT: The Southern African Human Genome Programme is a national initiative that aspires to unlock the unique genetic character of southern African populations for a better understanding of human genetic ...
  • Genetic resistance to mycobacterium tuberculosis infection and disease 

    Moller, Marlo; Kinnear, Craig J.; Orlova, Marianna; Kroon, Elouise E.; Van Helden, Paul D.; Schurr, Erwin; Hoal, Eileen G. (Frontiers Media, 2017)
    Natural history studies of tuberculosis (TB) have revealed a spectrum of clinical outcomes after exposure to Mycobacterium tuberculosis, the cause of TB. Not all individuals exposed to the bacterium will become diseased ...
  • Impact of alcohol consumption on tuberculosis treatment outcomes : a prospective longitudinal cohort study protocol 

    Myers, Bronwyn; Bouton, Tara C.; Ragan, Elizabeth J.; White, Laura F.; McIlleron, Helen; Theron, Danie; Parry, Charles D. H.; Horsburgh, C. R.; Warren, Robin M.; Jacobson, Karen R. (BioMed Central, 2018-09-29)
    Background: An estimated 10% of tuberculosis (TB) deaths are attributable to problematic alcohol use globally, however the causal pathways through which problem alcohol use has an impact on TB treatment outcome is not ...
  • Susceptibility to tuberculosis is associated with PI3K-dependent increased mobilization of neutrophils 

    Leisching, Gina R. (Frontiers Media, 2018)
    Neutrophilia is a condition commonly observed in patients with late-stage tuberculosis, but evidence suggests that increased neutrophil influx begins early after infection in susceptible hosts and functions to promote a ...
  • Direct susceptibility testing of Mycobacterium tuberculosis for Pyrazinamide by Use of the Bactec MGIT 960 system 

    Demers, Anne-Marie; Venter, Amour; Friedrich, Sven O.; Rojas-Ponce, Gabriel; Mapamba, Daniel; Jugheli, Levan; Sasamalo, Mohammed; Almeida, Deepak; Dorasamy, Afton; Jentsch, Ute; Gibson, Mara; Everitt, Daniel; Eisenach, Kathleen D.; Diacon, Andreas H. (American Society for Microbiology, 2016-05)
    Pyrazinamide (PZA) is a key antituberculosis drug, yet no rapid susceptibility test is commercially available. PZA drug susceptibility testing (DST) was performed directly on sputum samples from 327 patients and compared ...
  • GenoType MTBDRsl assay for resistance to second-line anti-tuberculosis drugs 

    Theron, Grant; Peter, Jonny; Richardson, Marty; Warren, Rob; Dheda, Keertan; Steingart, Karen R. (Cochrane, 2016-09-08)
    Background: Genotype® MTBDRsl (MTBDRsl) is a rapid DNA-based test for detecting specific mutations associated with resistance to fluoroquinolones and second-line injectable drugs (SLIDs) in Mycobacterium tuberculosis ...
  • The association of OASL and type I interferons in the pathogenesis and survival of intracellular replicating bacterial species 

    Leisching, Gina; Wiid, Ian; Baker, Bienyameen (Frontiers Media, 2017)
    The type I IFN response quickly became associated with its role in the innate immune response to viral infection. The past few years have seen the significance of IFNs expand in breadth to include non-viral pathogens. ...
  • Frequency of Mycobacterium tuberculosis-specific CD8+ T-cells in the course of anti-tuberculosis treatment 

    Axelsson-Robertson, Rebecca; Rao, Martin; Loxton, Andre G.; Walzl, Gerhard; Bates, Matthew; Zumla, Alimuddin; Maeurer, Markus (Elsevier, 2015)
    Anti-tuberculosis drug treatment is known to affect the number, phenotype, and effector functionality of antigen-specific T-cells. In order to objectively gauge Mycobacterium tuberculosis (MTB)-specific CD8+ T-cells at the ...
  • Mycobacterium bovis in a free-ranging black rhinoceros, Kruger National Park, South Africa, 2016 

    Miller, Michele A.; Buss, Peter E.; Van Helden, Paul D.; Parsons, Sven D. C. (Centers for Disease Control and Prevention, 2017)
    In 2016, an emaciated black rhinoceros (Diceros bicornis) was found in Kruger National Park, South Africa. An interferon-γ response was detected against mycobacterial antigens, and lung tissue was positive for Mycobacterium ...
  • Rv1460, a SufR homologue, is a repressor of the suf operon in mycobacterium tuberculosis 

    Willemse, Danicke; Weber, Brandon; Masino, Laura; Warren, Robin M.; Adinolfi, Salvatore; Pastore, Annalisa; Williams, Monique J. (Public Library of Science, 2018)
    Iron–sulphur (Fe-S) clusters are ubiquitous co-factors which require multi-protein systems for their synthesis. In Mycobacterium tuberculosis, the Rv1460-Rv1461-Rv1462-Rv1463-csd-Rv1465-Rv1466 operon (suf operon) encodes ...
  • Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals 

    Holzinger, Emily R.; Verma, Shefali S.; Moore, Carrie B.; Hall, Molly; De, Rishika; Gilbert-Diamond, Diane; Lanktree, Matthew B.; Pankratz, Nathan; Amuzu, Antoinette; Burt, Amber; Dale, Caroline; Dudek, Scott; Furlong, Clement E.; Gaunt, Tom R.; Kim, Daniel Seung; Riess, Helene; Sivapalaratnam, Suthesh; Tragante, Vinicius; Van Iperen, Erik P. A.; Brautba, Ariel; Carrell, David S.; Crosslin, David R.; Jarvik, Gail P.; Kuivaniemi, Helena; Kullo, Iftikhar J.; Larson, Eric B.; Rasmussen-Torvik, Laura J.; Tromp, Gerard; Baumert, Jens; Cruickshanks, Karen J.; Farrall, Martin; Hingorani, Aroon D.; Hovingh, G. K.; Kleber, Marcus E.; Klein, Barbara E.; Klein, Ronald; Koenig, Wolfgang; Lange, Leslie A.; Mӓrz, Winfried; North, Kari E.; Onland-Moret, N. Charlotte; Reiner, Alex P.; Talmud, Philippa J.; Van Der Schouw, Yvonne T.; Wilson, James G.; Kivimaki, Mika; Kumari, Meena; Moore, Jason H.; Drenos, Fotios; Asselbergs, Folkert W.; Keating, Brendan J.; Ritchie, Marylyn D. (BioMed Central, 2017)
    Background: The genetic etiology of human lipid quantitative traits is not fully elucidated, and interactions between variants may play a role. We performed a gene-centric interaction study for four different lipid traits: ...
  • Rutin as a potent antioxidant : implications for neurodegenerative disorders 

    Enogieru, Adaze Bijou; Haylett, William; Hiss, Donavon Charles; Bardien, Soraya; Ekpo, Okobi Eko (Hindawi, 2018)
    A wide range of neurodegenerative diseases (NDs), including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and prion diseases, share common mechanisms such as neuronal loss, apoptosis, mitochondrial ...
  • The functional interplay of low molecular weight thiols in Mycobacterium tuberculosis 

    Sao Emani, C.; Williams, M. J.; Wiid, I. J.; Baker, B. (BioMed Central, 2018-07-12)
    Background: Three low molecular weight thiols are synthesized by Mycobacterium tuberculosis (M.tb), namely ergothioneine (ERG), mycothiol (MSH) and gamma-glutamylcysteine (GGC). They are able to counteract reactive oxygen ...
  • A semi-automatic technique to quantify complex tuberculous lung lesions on 18F-fluorodeoxyglucose positron emission tomography/computerised tomography images 

    Malherbe, Stephanus T.; Dupont, Patrick; Kant, Ilse; Ahlers, Petri; Kriel, Magdalena; Loxton, Andre G.; Chen, Ray Y.; Via, Laura E.; Thienemann, Friedrich; Wilkinson, Robert J; Barry, Clifton E.; Griffith-Richards, Stephanie; Ellman, Annare; Ronacher, Katharina; Winter, Jill; Walzl, Gerhard; Warwick, James M. (Springer Open, 2018-06-25)
    Background: There is a growing interest in the use of 18F-FDG PET-CT to monitor tuberculosis (TB) treatment response. However, TB causes complex and widespread pathology, which is challenging to segment and quantify in a ...
  • Anti-mycobacterium tuberculosis activity of polyherbal medicines used for the treatment of tuberculosis in Eastern Cape, South Africa 

    Famewo, Elizabeth B.; Clarke, Anna M.; Wiid, Ian; Ngwane, Andile; Van Helden, Paul; Afolayan, Anthony J. (Makerere University, Faculty of Medicine, 2017)
    Background: The emergence of drug-resistant strains of Mycobacterium tuberculosis has become a global public health problem. Polyherbal medicines offer great hope for developing alternative drugs for the treatment of ...
  • Chronic obstructive pulmonary disease (COPD) : neutrophils, macrophages and lymphocytes in patients with anterior tuberculosis compared to tobacco related COPD 

    Guiedem, Elise; Ikomey, George Mondinde; Nkenfou, Celine; Walter, Pefura-Yone Eric; Mesembe, Martha; Chegou, Novel Njweipi; Jacobs, Graeme Brendon; Okomo Assoumou, Marie Claire (BioMed Central, 2018-03-27)
    Objective: The inflammatory profile of chronic obstructive pulmonary disease (COPD) related to tobacco is known in certain studies while that of the post tuberculosis form is not yet known. This study aimed to evaluate ...
  • Liver toxicity associated with tuberculosis chemotherapy in the REMoxTB study 

    Tweed, Conor Duncan; Wills, Genevieve Helen; Crook, Angela M.; Dawson, Rodney; Diacon, Andreas H.; Louw, Cheryl E.; McHugh, Timothy D.; Mendel, Carl; Meredith, Sarah; Mohapi, Lerato; Murphy, Michael E.; Murray, Stephen; Murthy, Sara; Nunn, Andrew J.; Phillips, Patrick P. J.; Singh, Kasha; Spigelman, M.; Gillespie, S. H. (BioMed Central, 2018-03-28)
    Background: Drug-induced liver injury (DILI) is a common complication of tuberculosis treatment. We utilised data from the REMoxTB clinical trial to describe the incidence of predisposing factors and the natural history ...
  • Cost analysis of rapid diagnostics for drug-resistant tuberculosis 

    Groessl, Erik J.; Ganiats, Theodore G.; Hillery, Naomi; Trollip, Andre; Jackson, Roberta L.; Catanzaro, Donald G.; Rodwell, Timothy C.; Garfein, Richard S.; Rodrigues, Camilla; Crudu, Valeriu; Victor, Thomas C.; Catanzaro, Antonino (BioMed Central, 2018-03-02)
    Background: Growth-based drug susceptibility testing (DST) is the reference standard for diagnosing drug-resistant tuberculosis (TB), but standard time to result (TTR) is typically ≥ 3 weeks. Rapid tests can reduce that ...

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