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Masters Degrees (Physiological Sciences)

Masters Degrees (Physiological Sciences)

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Recent Submissions

Grape seed extract affects adhesion competence and maturation of primary isolated rat myoblasts after contusion injury

Engelbrecht, Lize (Stellenbosch : Stellenbosch University, 2013-03)

ENGLISH ABSTRACT: Contusion injuries cause significant muscle damage, activating a series of cellular events. Satellite cells (SC), the key role players in muscle regeneration, are activated to proliferate and develop into ...
The relationship between HIF-1α and autophagy activity in the hypoxic environment of breast cancer

Mills, Justin (Stellenbosch : Stellenbosch University, 2013-03)

ENGLISH ABSTRACT: Introduction: Among the cancers that afflict females world-wide, neoplastic disease of breast tissue is the most frequently diagnosed form and the leading cause of cancer-related death. Conventional ...
The role of short-term starvation in sensitizing breast cancer to chemotherapy

Govender, Yogeshni (Stellenbosch : Stellenbosch University, 2013-03)

ENGLISH ABSTRACT: Introduction: Breast cancer is a major contributor to mortality in women worldwide. Although, anthracyclines, such as doxorubicin, are among the most valuable treatments for breast cancer, their clinical ...
The effect of MKP-1 inhibition on the cytotoxicity of chemotherapeutic drugs in breast cancer

Le Roux, Heloise (Stellenbosch : Stellenbosch University, 2012-12)

ENGLISH ABSTRACT: Introduction: Cancer is an emerging health problem in South Africa, with breast cancer being one of the leading cancers affecting women globally. Therefore, there is a need to find novel targets to improve ...
Leukocyte O-GlcNAcylation : a novel diagnostic tool for the earlier detection of type 2 diabetes mellitus?

Springhorn, Clare (Stellenbosch : Stellenbosch University, 2012-12)

ENGLISH ABSTRACT: Context: There are serious deficiencies in the current tests and criteria available for the diagnosis of diabetes. A novel screening method for the earlier and more efficient detection of type 2 diabetes ...
Predictive value of gene mutations as a diagnostic tool for ART resistance in a Zambian population

Maseko Phiri, Thabiso (Stellenbosch : Stellenbosch University, 2012-12)

Background: While Selection of reverse transcriptase (RT) mutation has been reported frequently, protease (PR) mutations on antiretroviral therapy (ART) including boosted Protease inhibitor (PI) have not been reported ...
The physiological effect of vitamin B12 deficiency in human blood

Abel, Stefan (Stellenbosch : Stellenbosch University, 1990-11)

ENGLISH ABSTRACT: The main aim of this workpiece was to establish the physiological parameters against which a vitamin Bu deficiency could be measured. A comparison between the hematological values of healthy patients ...
The effect of dietary Red Palm Oil on the functional recovery and the PKB/Akt pathway in the ischaemic/reperfused isolated rat heart

Odendaal, Louise (Stellenbosch : Stellenbosch University, 2007-12)

ENGLISH ABSTRACT: Introduction Cardiovascular disease is one of the leading causes of death in the world. Formation of harmful reactive oxygen species (ROS) is associated with several pathological conditions, and ...
Antioxidant (Oxiprovin TM) supplementation and muscle recovery from contusion injury - an in vivo study

Kruger, Maria Jacoba (Stellenbosch : Stellenbosch University, 2007-12)

ENGLISH ABSTRACT: Human studies on the response of muscle to contusion injury are limited, probably due to the large variability in injury severity and the non-specificity of clinical symptoms reported. To circumvent ...
Increased flux through the hexosamine biosynthetic pathway leads to the induction of acetol-CoA caboxylase gene expression in the heart

Imbriolo, Jamie (Stellenbosch : Stellenbosch University, 2008-03)

ENGLISH ABSTRACT: Gene expression of the cardiac isoform of acetyl-CoA carboxylase (ACCb) is induced in a glucose-dependent manner. ACCb produces malonyl-CoA, a potent inhibitor of mitochondrial fatty acid uptake. Previous ...
Muscle damage and adaptation in response to plyometric jumping

Isaacs, Ashwin Wayne (Stellenbosch : Stellenbosch University, 2012-03)

ENGLISH ABSTRACT: The aim of the study was to investigate skeletal muscle changes induced by an acute bout of plyometric exercise before and after plyometric training. The study consisted of an acute study and training ...
Association between antioxidant status and MnSOD Ala-9Val polymorphism in trained male athletes (rugby players) and sedentary male students controlled for antioxidant intake

Seele, Maria (Stellenbosch : Stellenbosch University, 2007-03)

ENGLISH ABSTRACT: The human body has developed an integrated antioxidant defence system to protect against free radical damage. Acute exercise may result in the increased generation of free radicals, including reactive ...
Exploring underlying mechanisms driving the onset of stress-induced insulin resistance

Otto, Delita (Stellenbosch : Stellenbosch University, 2012-03)

ENGLISH ABSTRACT: Physical and psychological stressors trigger activation of the hypothalamo-pituitary-adrenocortical (HPA) axis that leads to enhanced secretion of glucocorticoids e.g. cortisol. Moreover, chronic ...
Does the hexosamine biosynthetic pathway play a role in mediating the beneficial effects of oleic acid in the heart?

Harris, E. R. (Eurinah Roberta) (Stellenbosch : Stellenbosch University, 2012-03)

ENGLISH ABSTRACT: Background:Obesity is a growing global burden; current studies have projected the prevalence of obese / overweight individuals to increase to ~1.35 billion by 2030. A number of factors contribute to ...
ART-related body composition changes in adult women in a semi-rural South African context

De Bruto, Petro C. (Stellenbosch : Stellenbosch University, 2006-12)

ENGLISH ABSTRACT: The aim of this study was to investigate practical methods of monitoring AIDS related wasting and lipodystrophy in a resource-poor clinical setting with HIV infected women as the population group of ...

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