Nuclear Medicine
Collections in this community
Recent Submissions
-
Social anxiety disorder : Functional neuroimaging and social cognitive features
(Stellenbosch : Stellenbosch University, 2018-03)ENGLISH SUMMARY : Neuroimaging has enabled important progress in understanding the neurobiology of social anxiety disorder (SAD). Functional neuroimaging experiments in SAD have mostly focused on regional neural activity ...
-
Investigation into various aspects of radiolabelling somatostatin peptide derivatives with 68Ga eluted from a SnO2-based 68Ge/68Ga generator
(Stellenbosch : Stellenbosch University, 2018-03)ENGLISH SUMMARY : 68Ge/68Ga generators ensure the supply of 68Ga for positron emission tomography (PET), for instance for somatostatin receptor imaging with 68Ga-DOTA-labelled somatostatin analogues. There are various ...
-
Appropriate indications for positron emission tomography/computed tomography : College of Nuclear Physicians of the Colleges of Medicine of South Africa
(Health & Medical Publishing Group, 2016)Individualised patient treatment approaches demand precise determination of initial disease extent combined with early, accurate assessment of response to treatment, which is made possible by positron emission tomography/computed ...
-
An update on the management of breast cancer in Africa
(BioMed Central, 2017-02-14)ENGLISH SUMMARY : Background: There is limited information about the challenges of cancer management and attempts at improving outcomes in Africa. Even though South and North Africa are better resourceds to tackle the ...
-
Monitoring various eluate characteristics of the iThemba LABS SnO2-based 68Ge/68Ga generator over time and validation of quality control methods for the radiochemical purity assessment of 68Ga-labelled DOTA peptide formulations
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH SUMMARY : PET imaging with gallium-68 (68Ga) has become widely used due to the availability of 68Ge/68Ga generators and DOTA-derivatised peptide ligands for radiolabelling. The purpose of this study was to monitor ...
-
Evaluation of the effect of low and intermediate frequency electromagnetic waves on radiosensitivity
(Stellenbosch : Stellenbosch University, 2016-12)ENGLISH SUMMARY : The incidence of epidemic Kaposi’s sarcoma in HIV/AIDS patients is high due to their compromised immune system. HIV-positive individuals presenting with cancer tend to be more sensitive to ionizing radiation ...
-
Evaluation of small molecule inhibitors of HER2, PI3K, mTOR and Bcl-2 for their radiomodulatory effects in human breast cancer cell lines
(Stellenbosch : Stellenbosch University, 2016-12)ENGLISH SUMMARY : Breast cancer remains the most commonly diagnosed cancer in women. It is responsible for 32% of all cancers and 15% of all cancer-related deaths in females. Patients with triple-negative breast ...
-
Validation of radiochemical purity analysis methods used in two tertiary public hospitals in South Africa
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH SUMMARY : Radiopharmaceutical kits are supplied by manufacturers with package inserts containing information about the kit including validated methods of preparation and radiochemical purity (RCP) analysis. Validated ...
-
Targeting the EBFR and PI3K pathways as a therapeutic strategy for prostate cancer
(Stellenbosch : Stellenbosch University, 2015-04)ENGLISH ABSTRACT: Targeted therapy for prostate cancer may offer potential improvement over current conventional therapies because of its specificity. Although conventional treatments are effective, they are not curative ...
-
Radiosensitisation of low HER-2 expressing human breast cancer cell lines
(Stellenbosch : Stellenbosch University, 2015-04)ENGLISH ABSTRACT: Breast Cancer remains one of the world’s leading causes of cancer related deaths amongst women. Its treatment has evolved from invasive, highly toxic therapies to treatments that possess a higher ...
-
Hybrid imaging using low-dose, localizing computed tomography enhances lesion localization in renal hyperparathyroidism
(Lippincott, Williams & Wilkins, 2014-03)Background Preoperative localization of parathyroid lesions is potentially beneficial in renal patients with hyperparathyroidism. The aim of this study was to determine the localizing value of hybrid single-photon emission ...
-
Extended Cr-51 RBC combined with Tc-99m RBC for the detection and localisation of occult GIT bleeding
(Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: Background Occult blood loss from the gastrointestinal tract (GIT), causing iron deficiency often with anaemia, can be diagnostically and therapeutically challenging. This is because the endoscopic and ...
-
The added value of SPECT/CT in complicated osteomyelitis
(Stellenbosch : Stellenbosch University, 2013-12)ENGLISH ABSTRACT: Background: The detection of bone infection can be very difficult especially in bone with altered structure due to prior trauma or surgical procedures. Complicated osteomyelitis (COM) is becoming a public ...
-
Imaging of renal hyperparathyroidism using SPECT/CT with low-dose localizing CT
(Stellenbosch : Stellenbosch University, 2013-12)ENGLISH ABSTRACT: Background: Hybrid imaging using single photon emission computed tomography/low dose (x-ray) computed tomography (SPECT/LDCT) is of benefit in preoperative scintigraphy of primary hyperparathyroidism. The ...
-
Nuclear medicine in South Africa
(HMPG, 2003-08)ENGLISH ABSTRACT: Why should an issue of CME, a publication primarily directed at generalists, be devoted to nuclear medicine? I am reminded from time to time of how unfamiliar many of my colleagues are with this ...
-
An investigation of the contribution of Single Photon Emission Computed Tomography to the diagnosis of skeletal metastases using bone scan in the African context
(Stellenbosch : Stellenbosch University, 2003-12)ENGLISH ABSTRACT: Planar bone scintigraphy is highly sensitive but it may not be sensitive enough to detect subtle lesions in complex bony structures such as the spine. The accurate anatomic localisation of lesions in ...
-
Working towards the implementaion of an international accreditation programme in a Nuclear Medicine Department of a South African teaching hospital
(Stellenbosch : Stellenbosch University, 2005-04)ENGLISH ABSTRACT: Introduction: Quality assurance in Nuclear Medicine is of utmost importance in order to ensure optimal scintigraphic results and correct patient management. A customised Quality Management System (QMS) ...
-
The effect of reconstruction algorithms (iterative versus filtered backprojection) on the diagnosis of single pulmonary nodules using Thallium-201 and Technetium-99m MIBI SPECT
(Stellenbosch : Stellenbosch University, 2004-04)ENGLISH ABSTRACT: This study involved 33 patients, 19 men and 14 women. The age range was wide (20-90 years) and median age was 57 years. These patients had a single pulmonary nodule (SPN) defined radiologically as a ...
-
Two simple inexpensive photographic methods for viewing ECG-gated radionuclide blood pool images
(HMPG, 1979-04)Although the ECG-gated radionuclide blood pool scan (GBPS) has become an established method for studying regional myocardial wall motion, it is usually performed with the aid of an expensive computer system. A simple, ...
-
Ventilasiestudies van die long met kripton-81m
(HMPG, 1981-08)During a 2-year study period it was found that krypton-81m was useful in routine clinical practice. During this period 1563 technetium-99m perfusion studies and 807 krypton-81m ventilation studies were performed. A distinct ...
-
First-pass determination of the right ventricular ejection fraction using two regions of interest and the right anterior oblique view
(HMPG, 1984)The right ventricular ejection fraction (RVEF) was determined on the right anterior oblique view in 9 patients during the first pass of a bolus of technetium-99m employing a gamma camera with high count-rate capability. ...
-
Quantifying the risks of radiation exposure
(Health & Medical Publishing Group, 1986-09)The considerations leading to the recommendation of dose-equivalent limits by the International Commision for Radiological Protection are outlined. The dose-equivalent limits are based on radiation risk factors estimated ...
-
The elimination of errors caused by prior technetium-99m scintigraphy on iodine-131 thyroid uptake measurements.
(Health & Medical Publishing Group, 1987)Coincidence summing of technetium-99m (99mTc) pulses may disturb iodine-131 (131I) thyroid uptake measurements if these are obtained after 99mTc thyroid scintigraphy performed on the same day. The magnitude of the error ...
-
A case for the provision of positron emission tomography (PET) in South African public hospitals
(Health and Medical Publishing Group, 2006-07)Nuclear medicine is expanding into new areas of clinical practice, of which positron emission tomography (PET) is an example. As in new treatments with labelled monoclonal antibodies, especially for lymphoma, the wide ...
-
Single photon emission computed tomography (SPECT) of anxiety disorders before and after treatment with citalopram
(BioMed Central, 2004-10)Background: Several studies have now examined the effects of selective serotonin reuptake inhibitor (SSRI) treatment on brain function in a variety of anxiety disorders including obsessive-compulsive disorder (OCD), ...
-
Brain SPECT in patients with neuropsychiatric SLE : the additional value of semi-quantitative analysis
(Stellenbosch : University Stellenbosch, 2009-12)ENGLISH ABSTRACT: Introduction: There is conflicting data on the value of single photon emission tomography (SPECT) for the diagnosis of neuropsychiatric SLE (NPSLE). Visual assessment of brain SPECT scans is the standard ...
-
Pulmonary embolism diagnosis : a clinical comparison between conventional planar and SPECT V/Q imaging using Krypton 81m – with CTPA as the gold standard
(Stellenbosch : University of Stellenbosch, 2010-03)ENGLISH ABSTRACT: Single photon emission computed tomography (SPECT) with a superior contrast resolution has been shown to be more sensitive and specific with a lower nondiagnostic rate than planar imaging in many nuclear ...
-
The added value of SPECT/CT in the evaluation of equivocal skeletal lesions in patients with known malignant disease
(Stellenbosch : University of Stellenbosch, 2010-03)ENGLISH SUMMARY: Introduction: Bone scintigraphy is used extensively in evaluating metastatic disease. There are currently no clear recommendations for the use of SPECT/CT in metastatic bone disease. Existing procedural ...
-
Response to radioiodine in male hyperthyroid patients at Tygerberg Hospital
(Stellenbosch : University of Stellenbosch, 2009-03)ENGLISH ABSTRACT: Radioiodine therapy is reputed to yield poorer results in male patients than in females. We retrospectively reviewed the records of 308 patients treated with radioiodine-131 (RAI) for Graves’ disease ...
-
Optimal utilization of gamma camera time in Tc-99m MDP bone scintigraphy
(Stellenbosch : University of Stellenbosch, 2007-03)Introduction: Whole body bone scintigraphy with Tc-99m MDP is able to provide a survey of the entire skeleton. The question arises if it is mandatory to perform a whole body bone scan in all patients, irrespective of the ...
RSS 1.0