Nuclear Medicine

Influence of acquisition time and smoothing parameters on Ga-68 wholebody PET/CT image quality

Diale, Boitshoko Phenyo (Stellenbosch : Stellenbosch University, 2020-12)

ENGLISH SUMMARY : PET/CT image optimization has been extensively investigated for 18F–FDG PET imaging. Although 68Ga–tracers are already widely used in PET, optimized imaging and reconstruction are still missing. The aim ...

Optimization of production methods for gallium-68 PET radiopharmaceuticals in a hospital radiopharmacy

Le Roux, Johannes Stephanus (Stellenbosch : Stellenbosch University, 2020-12)

ENGLISH SUMMARY : Production of radiopharmaceuticals intended for human use and research purposes is generally performed in well-equipped commercial or research facilities that usually have access to advanced equipment for ...

Implementation of guidelines on hospital radiopharmacy in low-income settings

Ekoume, Fany Pricile (Stellenbosch : Stellenbosch University, 2020-12)

ENGLISH SUMMARY : Although radiopharmacy is more than 50 years old, it is still in a stage of rapid development. This dissertation focuses on quality issues in radiopharmacies in developing countries. Guidelines for ...

Validation of a cost-effective alternative for a radiochromatography method to be used in a developing country

Ekoume, F. P.; Boersma, H. H.; Dong a Zok, F.; Rubow, S. M. (SpringerOpen (part of Springer Nature), 2020-04-10)

Introduction: The radiochemical purity (RCP) of technetium-99m labelled radiopharmaceuticals (RP) is important to ensure optimal scintigraphic image quality. In low-income settings, it may not be possible to use compendial ...

Methamphetamine dependence with and without psychotic symptoms : a multi-modal brain imaging study

Vuletica, Daniella; Dupontc, Patrick; Robertsond, Frances; Warwick, James M.; Zeevaartc, Jan Rijn; Steina, Dan J. (Elsevier, 2018)

Objective: Methamphetamine dependence can lead to psychotic symptoms which may be mediated by frontal, striatal, limbic, and thalamic regions. There are few neuroimaging data that allow comparison of individuals with ...

Validation of equations to estimate glomerular filtration rate in South Africans of mixed ancestry

Holness, Jen L.; Bezuidenhout, K.; Davids, M. R.; Warwick, J. M. (Health & Medical Publishing Group, 2020-02-26)

Background. The Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations are two commonly used formulae to estimate glomerular filtration rate (GFR) in adults. ...

The College of Nuclear Physicians of South Africa practice guidelines on peptide receptor radionuclide therapy in neuroendocrine tumours

Lawal, I.; Louw, L.; Warwick, James M.; Nyakale, N.; Steyn, R.; Lengana, T.; Ellmann, A.; Kotze, T; Vangu, M.; Vorster, M.; Sathekge, M. (Health and Medical Publishing Group, 2018)

Background: Peptide receptor radionuclide therapy (PRRT) for metastatic or inoperable neuroendocrine tumours (NETs) is a systemic therapy which targets somatostatin receptors overexpressed by differentiated NETs for ...

Glomerular filtration rate measurement and estimation : improvement and validation of existing methods

Holness, Jennifer Lyn (Stellenbosch : Stellenbosch University, 2019-12)

ENGLISH SUMMARY : Glomerular filtration rate (GFR) is regarded as the best measure of kidney function. It can either be measured or estimated. This dissertation aims to provide a better understanding of GFR measurement in ...

Social anxiety disorder : Functional neuroimaging and social cognitive features

Doruyter, Alexander Govert George (Stellenbosch : Stellenbosch University, 2018-03)

ENGLISH SUMMARY : Neuroimaging has enabled important progress in understanding the neurobiology of social anxiety disorder (SAD). Functional neuroimaging experiments in SAD have mostly focused on regional neural activity ...

Investigation into various aspects of radiolabelling somatostatin peptide derivatives with 68Ga eluted from a SnO2-based 68Ge/68Ga generator

Prince, Deidre Mabel (Stellenbosch : Stellenbosch University, 2018-03)

ENGLISH SUMMARY : 68Ge/68Ga generators ensure the supply of 68Ga for positron emission tomography (PET), for instance for somatostatin receptor imaging with 68Ga-DOTA-labelled somatostatin analogues. There are various ...

Appropriate indications for positron emission tomography/computed tomography : College of Nuclear Physicians of the Colleges of Medicine of South Africa

Sathekge, Mike; Warwick, James M.; Doruyter, Alex; Vorster, Mariza (Health & Medical Publishing Group, 2016)

Individualised patient treatment approaches demand precise determination of initial disease extent combined with early, accurate assessment of response to treatment, which is made possible by positron emission tomography/computed ...

An update on the management of breast cancer in Africa

Vanderpuye, V.; Grover, S.; Hammad, N.; Prabhakar, Pooja; Simonds, H.; Olopade, F.; Stefan, D. C. (BioMed Central, 2017-02-14)

ENGLISH SUMMARY : Background: There is limited information about the challenges of cancer management and attempts at improving outcomes in Africa. Even though South and North Africa are better resourceds to tackle the ...

Monitoring various eluate characteristics of the iThemba LABS SnO2-based 68Ge/68Ga generator over time and validation of quality control methods for the radiochemical purity assessment of 68Ga-labelled DOTA peptide formulations

Davids, Claudia Ruby (Stellenbosch : Stellenbosch University, 2017-03)

ENGLISH SUMMARY : PET imaging with gallium-68 (68Ga) has become widely used due to the availability of 68Ge/68Ga generators and DOTA-derivatised peptide ligands for radiolabelling. The purpose of this study was to monitor ...

Evaluation of the effect of low and intermediate frequency electromagnetic waves on radiosensitivity

Chinhengo, Angela (Stellenbosch : Stellenbosch University, 2016-12)

ENGLISH SUMMARY : The incidence of epidemic Kaposi’s sarcoma in HIV/AIDS patients is high due to their compromised immune system. HIV-positive individuals presenting with cancer tend to be more sensitive to ionizing radiation ...

Evaluation of small molecule inhibitors of HER2, PI3K, mTOR and Bcl-2 for their radiomodulatory effects in human breast cancer cell lines

Hamunyela, Roswita Hambeleleni (Stellenbosch : Stellenbosch University, 2016-12)

ENGLISH SUMMARY : Breast cancer remains the most commonly diagnosed cancer in women. It is responsible for 32% of all cancers and 15% of all cancer-related deaths in females. Patients with triple-negative breast ...