Background: DJ-1 forms part of the neuronal cellular defence mechanism against oxidative insults, due
to its ability to undergo self-oxidation. Oxidative stress has been implicated in the pathogenesis of central
nervous ...
Background: The assimilation of nitrogen is an essential process in all prokaryotes, yet a relatively limited amount of information is available on nitrogen metabolism in the mycobacteria. The physiological role and ...
Van der Merwe, Ruben Gerhard(Stellenbosch : Stellenbosch University, 2012-12)
ENGLISH ABSTRACT: Mycobacterium tuberculosis, the causative organism of tuberculosis (TB), is a major cause for mortality and
morbidity world-wide with a death toll only second to HIV among infectious diseases. Drug ...
ENGLISH ABSTRACT: Tuberculosis (TB) has been declared a global health emergency by the World Health Organisation, and consequently there is an urgency to develop improved methods of diagnosis and treatment. Despite the ...
Van der Merwe, Celia(Stellenbosch : Stellenbosch University, 2012-12)
ENGLISH ABSTRACT: Parkinson’s disease (PD) is a neurodegenerative movement disorder characterized by the loss of dopaminergic neurons in the substantia nigra of the midbrain. Although the aetiology of PD is still not fully ...
ENGLISH ABSTRACT: There is a progressive maturation of the immune system from infancy to adulthood. The
immature immune system in early life is characterised by impaired macrophage function
and antigen presentation as ...
Barreiro, Luis B.Neyrolles, OlivierBabb, Chantal L.Tailleux, LudovicQuach, HeleneMcElreavey, KenVan Helden, Paul D.Hoal, Eileen G.Gicquel, BrigitteQuintana-Murci, Lluis(Public Library of Science (PLOS), 2006-01)
Background
Tuberculosis, which is caused by Mycobacterium tuberculosis, remains one of the leading
causes of mortality worldwide. The C-type lectin DC-SIGN is known to be the major M.
tuberculosis receptor on human ...
ENGLISH ABSTRACT: Sequence analysis showed that the essential glnA1 gene of Mycobacterium tuberculosis might
be closely related to an actinomycetes progenitor sequence and that this sequence may have
undergone duplication ...
ENGLISH ABSTRACT: In hypertrophic cardiomyopathy (HCM), an autosomal dominant disorder, hypertrophy is variable
within and between families carrying the same causal mutation, suggesting a role for modifier genes.
Associations ...
Golakai, Hawa Jande(Stellenbosch : Stellenbosch University, 2008-03)
ENGLISH ABSTRACT: Setting
This study was conducted in the Tygerberg area of Cape Town in South Africa.
Background
A third of the world’s population is latently infected with Mycobacterium tuberculosis,
and correlates ...
Kinnear, C. J. (Craig John)(Stellenbosch : Stellenbosch University, 2007-12)
ENGLISH ABSTRACT: Obsessive-compulsive disorder is a severe, debilitating psychiatric disorder for which the
underlying molecular aetiology still remains unclear. Evidence from family studies have
suggested that OCD may ...
ENGLISH ABSTRACT: Application of molecular fingerprinting highlights transmission as the driving force behind the
drug resistant epidemic in South Africa. Different strains dominate within different geographical
regions, ...
Djoba Siawaya, Joel Fleury(Stellenbosch : Stellenbosch University, 2008-03)
ENGLISH ABSTRACT: Setting
Study conducted in Tygerberg, Cape Town in South Africa.
Hypothesis
Host biomarkers associated with the antimycobacterial immune response during active infection with M. tuberculosis and during ...
ENGLISH ABSTRACT: South Africa is ranked amongst the top tuberculosis (TB) burden countries in the world and
the Western Cape has a particularly high incidence of the disease. Previous studies have
showed that several ...
ENGLISH ABSTRACT: Anti-tuberculosis drugs target specific essential cellular processes and structural components. The first line drug, rifampicin (RIF) is a RNA polymerase inhibitor which targets the β-subunit and subsequently ...