Are early and late preeclampsia distinct subclasses of the diseasewhat does the placenta reveal
Date
2010
Authors
Van Der Merwe J.L.
Hall D.R.
Wright C.
Schubert P.
Grove D.
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Abstract
Objective. To compare histopathological differences in placentas from early- and late-onset preeclampsia, as well as late-onset preeclampsia and normal term deliveries. Methods. This prospective study was performed at Tygerberg Hospital, a secondary and tertiary referral center in South Africa. Placentas from 100 women, 25 each with early and late-onset preeclampsia, and an equal number of controls matched for gestational age, underwent routine preparation and were evaluated independently by two pathologists in a strictly predetermined, standardized manner. Results. Compared to late preeclampsia, placentas in the early preeclampsia group were smaller (p < 0.01), had more infarction (odds ratio [OR] 4.03, 95 confidence interval [CI] 1.213.5) and inappropriate maturation (OR 16.62, 95 CI 4.168.0). Placentas from the late-onset preeclampsia group showed increased decidual arteriopathy (OR 5.09, 95 CI 1.4517.92) and abruptio placentae (OR 5.41, 95 CI 1.0128.79) compared to controls. Conclusions. The early- and late-onset preeclampsia placentas showed clear histopathological differences, whereas late-onset preeclampsia and normal term placentas differed less. These findings support the contention that early- and late-onset preeclampsia are different subclasses of disease. © 2010 Informa Healthcare USA, Inc.
Description
Keywords
adult, artery disease, article, comparative study, delivery, early onset preeclampsia, female, gestational age, heart infarction, histopathology, human, human tissue, late onset preeclampsia, major clinical study, pathology, placenta, preeclampsia, prospective study, solutio placentae, South Africa, Adult, Case-Control Studies, Female, Gestational Age, Humans, Odds Ratio, Placenta, Pre-Eclampsia, Pregnancy
Citation
Hypertension in Pregnancy
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