Are early and late preeclampsia distinct subclasses of the diseasewhat does the placenta reveal

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dc.contributor.authorVan Der Merwe J.L.
dc.contributor.authorHall D.R.
dc.contributor.authorWright C.
dc.contributor.authorSchubert P.
dc.contributor.authorGrove D.
dc.date.accessioned2011-05-15T16:16:36Z
dc.date.available2011-05-15T16:16:36Z
dc.date.issued2010
dc.description.abstractObjective. To compare histopathological differences in placentas from early- and late-onset preeclampsia, as well as late-onset preeclampsia and normal term deliveries. Methods. This prospective study was performed at Tygerberg Hospital, a secondary and tertiary referral center in South Africa. Placentas from 100 women, 25 each with early and late-onset preeclampsia, and an equal number of controls matched for gestational age, underwent routine preparation and were evaluated independently by two pathologists in a strictly predetermined, standardized manner. Results. Compared to late preeclampsia, placentas in the early preeclampsia group were smaller (p < 0.01), had more infarction (odds ratio [OR] 4.03, 95 confidence interval [CI] 1.213.5) and inappropriate maturation (OR 16.62, 95 CI 4.168.0). Placentas from the late-onset preeclampsia group showed increased decidual arteriopathy (OR 5.09, 95 CI 1.4517.92) and abruptio placentae (OR 5.41, 95 CI 1.0128.79) compared to controls. Conclusions. The early- and late-onset preeclampsia placentas showed clear histopathological differences, whereas late-onset preeclampsia and normal term placentas differed less. These findings support the contention that early- and late-onset preeclampsia are different subclasses of disease. © 2010 Informa Healthcare USA, Inc.
dc.description.versionArticle
dc.identifier.citationHypertension in Pregnancy
dc.identifier.citation29
dc.identifier.citation4
dc.identifier.issn10641955
dc.identifier.other10.3109/10641950903572282
dc.identifier.urihttp://hdl.handle.net/10019.1/13854
dc.subjectadult
dc.subjectartery disease
dc.subjectarticle
dc.subjectcomparative study
dc.subjectdelivery
dc.subjectearly onset preeclampsia
dc.subjectfemale
dc.subjectgestational age
dc.subjectheart infarction
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectlate onset preeclampsia
dc.subjectmajor clinical study
dc.subjectpathology
dc.subjectplacenta
dc.subjectpreeclampsia
dc.subjectprospective study
dc.subjectsolutio placentae
dc.subjectSouth Africa
dc.subjectAdult
dc.subjectCase-Control Studies
dc.subjectFemale
dc.subjectGestational Age
dc.subjectHumans
dc.subjectOdds Ratio
dc.subjectPlacenta
dc.subjectPre-Eclampsia
dc.subjectPregnancy
dc.titleAre early and late preeclampsia distinct subclasses of the diseasewhat does the placenta reveal
dc.typeArticle
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