Changes in host immune–endocrine relationships during tuberculosis treatment in patients with cured and failed treatment outcomes

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dc.contributor.authorKleynhans, Leanieen_ZA
dc.contributor.authorRuzive, Sheenaen_ZA
dc.contributor.authorEhlers, Lizaanen_ZA
dc.contributor.authorThiart, Lanien_ZA
dc.contributor.authorChegou, Novel N.en_ZA
dc.contributor.authorConradie, Magdaen_ZA
dc.contributor.authorKriel, Magdalenaen_ZA
dc.contributor.authorKim Stanleyen_ZA
dc.contributor.authorVan Der Spuy, Gian D.en_ZA
dc.contributor.authorKidd, Martinen_ZA
dc.contributor.authorVan Heldenen_ZA
dc.contributor.authorWalzl, Gerharden_ZA
dc.contributor.authorRonacher, Katharinaen_ZA
dc.date.accessioned2017-07-06T08:10:24Z
dc.date.available2017-07-06T08:10:24Z
dc.date.issued2017
dc.descriptionCITATION: Kleynhans, L., et al. 2017. Changes in host immune–endocrine relationships during tuberculosis treatment in patients with cured and failed treatment outcomes. Frontiers in Immunology, 8:690, doi:10.3389/fimmu.2017.00690.en_ZA
dc.descriptionThe original publication is available at http://journal.frontiersin.orgen_ZA
dc.descriptionPublication of this article was funded by the Stellenbosch University Open Access Fund.en_ZA
dc.description.abstractA bidirectional communication between the immune and endocrine systems exists and facilitates optimum responses in the host during infections. This is in part achieved through changes in secretion patterns of hypothalamic hormones induced by inflammatory cytokines. The aim of this study was to elucidate the immune–endocrine alterations during tuberculosis (TB) treatment in patients with cured and failed TB treatment outcomes. Blood samples were collected from 27 cured and 10 failed patients and hormone as well as cytokine concentrations quantified at baseline, week 4, and month 6 of TB treatment. Hormone profiles of the two treatment outcome groups were different from each other prior to as well as during TB treatment. Treatment response effects were observed for cortisol, estradiol, T3, T4 ghrelin, leptin, amylin, adiponectin, and dehydroepiandrosterone (DHEA). Trends suggest that T4, amylin, and DHEA concentrations were different between treatment outcomes, although these did not reach statistical significance. Relationships between endocrine and inflammatory markers and the biological pathways involved differed between cured and failed treatment patients. These results highlight the complex interaction between the endocrine and immune system during active TB disease and throughout treatment and suggest that endocrine markers in conjunction with inflammatory markers may be useful in predicting unfavorable treatment outcomes.en_ZA
dc.description.versionPublisher's versionen_ZA
dc.format.extent13 pages : illustrations (some colour)en_ZA
dc.identifier.citationKleynhans, L., et al. 2017. Changes in host immune–endocrine relationships during tuberculosis treatment in patients with cured and failed treatment outcomes. Frontiers in Immunology, 8:690, doi:10.3389/fimmu.2017.00690en_ZA
dc.identifier.issn1664-3224 (online)
dc.identifier.otherdoi:10.3389/fimmu.2017.00690
dc.identifier.urihttp://hdl.handle.net/10019.1/101926
dc.language.isoen_ZAen_ZA
dc.publisherFrontiers Mediaen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectTuberculosis -- Treatmenten_ZA
dc.subjectBiochemical markersen_ZA
dc.subjectImmune systemen_ZA
dc.subjectCytokinesen_ZA
dc.titleChanges in host immune–endocrine relationships during tuberculosis treatment in patients with cured and failed treatment outcomesen_ZA
dc.typeArticleen_ZA
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