Distribution of brain infarction in children with tuberculous meningitis and correlation with outcome score at 6 months

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dc.contributor.authorAndronikou S.
dc.contributor.authorWilmshurst J.
dc.contributor.authorHatherill M.
dc.contributor.authorVanToorn R.
dc.date.accessioned2011-05-15T16:17:42Z
dc.date.available2011-05-15T16:17:42Z
dc.date.issued2006
dc.description.abstractBackground: Prognostic indicators for tuberculous meningitis (TBM) offer realistic expectations for parents of affected children. Infarctions affecting the basal ganglia are associated with a poor outcome. Objective: To correlate the distribution of infarction in children with TBM on CT with an outcome score (OS). Materials and methods: CT brain scans in children with TBM were retrospectively reviewed and the distribution of infarctions recorded. The degree of correlation with OS at 6 months was determined. Results: There was a statistically significant association between all sites of infarction (P=0.0001-0.001), other than hemispheric (P=0.35), and outcome score. There was also a statistically significant association between all types of infarction (P=0.0001-0.02), other than hemispheric (P=0.05), and overall poor outcome. The odds ratio for poor outcome with bilateral basal ganglia and internal capsule infarction was 12. The odds ratio for poor outcome with 'any infarction' was 4.91 (CI 2.24-10.74), with 'bilateral infarctions' 8.50 (CI 2.49-28.59), with basal ganglia infarction 5.73 (CI 2.60-12.64), and for hemispheric infarction 2.30 (CI 1.00-5.28). Conclusion: Infarction is associated with a poor outcome unless purely hemispheric. MRI diffusion-weighted imaging was not part of this study, but is likely to play a central role in detecting infarctions not demonstrated by CT. © Springer-Verlag 2006.
dc.description.versionArticle
dc.identifier.citationPediatric Radiology
dc.identifier.citation36
dc.identifier.citation12
dc.identifier.issn03010449
dc.identifier.other10.1007/s00247-006-0319-7
dc.identifier.urihttp://hdl.handle.net/10019.1/14333
dc.subjectadolescent
dc.subjectarticle
dc.subjectbasal ganglion
dc.subjectbrain infarction
dc.subjectcapsula interna
dc.subjectchild
dc.subjectcomputer assisted tomography
dc.subjectcorrelation analysis
dc.subjectdiagnostic accuracy
dc.subjectdiagnostic value
dc.subjectdiffusion weighted imaging
dc.subjectdisease association
dc.subjectfemale
dc.subjecthuman
dc.subjectimage analysis
dc.subjectinfant
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmedical record review
dc.subjectnuclear magnetic resonance imaging
dc.subjectoutcomes research
dc.subjectpriority journal
dc.subjectprognosis
dc.subjectscoring system
dc.subjectstatistical significance
dc.subjecttuberculous meningitis
dc.subjectAdolescent
dc.subjectBrain
dc.subjectBrain Infarction
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectFemale
dc.subjectHumans
dc.subjectInfant
dc.subjectMale
dc.subjectOdds Ratio
dc.subjectPrognosis
dc.subjectRetrospective Studies
dc.subjectTomography, X-Ray Computed
dc.subjectTuberculosis, Meningeal
dc.titleDistribution of brain infarction in children with tuberculous meningitis and correlation with outcome score at 6 months
dc.typeArticle
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