Ampicillin and metronidazole treatment in preterm labour: A multicentre, randomised controlled trial

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dc.contributor.authorNorman K.
dc.contributor.authorPattinson R.C.
dc.contributor.authorDe Souza J.
dc.contributor.authorDe Jong P.
dc.contributor.authorMoller G.
dc.contributor.authorKirsten G.
dc.date.accessioned2011-05-15T16:15:48Z
dc.date.available2011-05-15T16:15:48Z
dc.date.issued1994
dc.description.abstractObjective: To ascertain whether adjuvant ampicillin and metronidazole given to women in preterm labour with intact membranes would prolong pregnancy and decrease the perinatal mortality and morbidity. Design: A multicentre, prospective, randomised controlled trial. Setting: Three perinatal centres serving an indigent population. Subjects: Eighty-one women in active preterm labour with otherwise uncomplicated singleton pregnancies between 26 and 34 weeks gestation or an ultrasound fetal weight estimate of 800 g to 1500 g. Interventions: The study group received ampicillin and metronidazole for five days. The control group received no antibiotics. In all women contractions were suppressed with hexoprenaline and indomethacin for 24 h, and betamethasone was given for fetal lung maturity. Main outcome measures: Days gained and perinatal mortality and morbidity. Results: The study (n = 43) and control groups (n = 38) were comparable at entry. In those receiving ampicillin and metronidazole the pregnancy was significantly prolonged (median 15 days versus 2.5 days, P = 0.04) with significantly more women still pregnant after seven days (63% versus 37%,P = 0.03, OR 0.34 95% CI 0.13-0.94). Significantly more infants in the control group developed necrotising enterocolitis than in the study group (5 versus 0, P = 0.02). Conclusion: Adjuvant ampicillin and metronidazole in the management of women in preterm labour with intact membranes significantly prolonged the pregnancy and decreased neonatal morbidity.
dc.description.versionArticle
dc.identifier.citationBritish Journal of Obstetrics and Gynaecology
dc.identifier.citation101
dc.identifier.citation5
dc.identifier.issn03065456
dc.identifier.urihttp://hdl.handle.net/10019.1/13495
dc.subjectampicillin
dc.subjecthexoprenaline
dc.subjectindometacin
dc.subjectmetronidazole
dc.subjectadult
dc.subjectarticle
dc.subjectclinical trial
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectdrug efficacy
dc.subjectfemale
dc.subjecthuman
dc.subjectintravenous drug administration
dc.subjectmajor clinical study
dc.subjectmulticenter study
dc.subjectoral drug administration
dc.subjectpregnancy
dc.subjectpremature labor
dc.subjectpriority journal
dc.subjectrandomized controlled trial
dc.subjectrectal drug administration
dc.subjectAdult
dc.subjectAmpicillin
dc.subjectBirth Weight
dc.subjectDrug Therapy, Combination
dc.subjectFemale
dc.subjectGestational Age
dc.subjectHumans
dc.subjectMetronidazole
dc.subjectObstetric Labor, Premature
dc.subjectPregnancy
dc.subjectPregnancy Outcome
dc.subjectProspective Studies
dc.subjectTime Factors
dc.titleAmpicillin and metronidazole treatment in preterm labour: A multicentre, randomised controlled trial
dc.typeArticle
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