An HIV-infected infant with Bacille Calmette-Guérin disease, recurrent and multidrug-resistant tuberculosis complicated by acute cor pulmonale and hepatitis while on antiretroviral therapy

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dc.contributor.authorvan Montfrans J.M.
dc.contributor.authorRabie H.
dc.contributor.authorSchaaf H.S.
dc.contributor.authorHesseling A.C.
dc.contributor.authorCotton M.F.
dc.contributor.authorShipton S.E.
dc.contributor.authorVictor T.
dc.date.accessioned2011-05-15T16:18:10Z
dc.date.available2011-05-15T16:18:10Z
dc.date.issued2007
dc.description.abstractWe describe the management of an HIV-infected infant with multisystem disease. The infant presented with severe disease at 3 months of age. Initiation of antiretroviral therapy (ART) was delayed through initial lack of access, after which she developed immune reconstitution inflammatory syndrome to BCG. At this time she was also infected with Mycobacterium tuberculosis, with a later recurrence due to multidrug-resistant (MDR) tuberculosis (TB). During this episode she presented with acute cor pulmonale, possibly due to a pulmonary embolus and also transaminitis. Although such infants are seen frequently in sub-Saharan Africa, there are few guidelines or case descriptions to assist clinicians.
dc.description.versionArticle
dc.identifier.citationSouthern African Journal of HIV Medicine
dc.identifier.citation26
dc.identifier.issn16089693
dc.identifier.urihttp://hdl.handle.net/10019.1/14541
dc.subjectamikacin
dc.subjectamphotericin B
dc.subjectBCG vaccine
dc.subjectcefuroxime
dc.subjectcotrimoxazole
dc.subjectdidanosine
dc.subjectethambutol
dc.subjectethionamide
dc.subjectheparin
dc.subjectHuman immunodeficiency virus antibody
dc.subjecthydrochlorothiazide
dc.subjectisoniazid
dc.subjectofloxacin
dc.subjectpyrazinamide
dc.subjectrifampicin
dc.subjectritonavir
dc.subjectstavudine
dc.subjectterizidone
dc.subjecttuberculostatic agent
dc.subjectwarfarin
dc.subjectabscess drainage
dc.subjectanticoagulation
dc.subjectarticle
dc.subjectbacterium culture
dc.subjectBCG vaccination
dc.subjectcase report
dc.subjectCD4 lymphocyte count
dc.subjectdifferential diagnosis
dc.subjectdrug dose increase
dc.subjectdrug sensitivity
dc.subjectdrug substitution
dc.subjectdrug withdrawal
dc.subjectenzyme linked immunosorbent assay
dc.subjecthepatitis
dc.subjecthighly active antiretroviral therapy
dc.subjecthuman
dc.subjectHuman immunodeficiency virus 1
dc.subjectHuman immunodeficiency virus infection
dc.subjectinfant
dc.subjectinfant disease
dc.subjectliver toxicity
dc.subjectmultidrug resistance
dc.subjectPneumocystis pneumonia
dc.subjectpolymerase chain reaction
dc.subjectpulmonary hypertension
dc.subjectthorax radiography
dc.subjecttuberculin test
dc.subjecttuberculosis
dc.subjecttuberculous lymphadenitis
dc.titleAn HIV-infected infant with Bacille Calmette-Guérin disease, recurrent and multidrug-resistant tuberculosis complicated by acute cor pulmonale and hepatitis while on antiretroviral therapy
dc.typeArticle
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