Association of deworming with reduced eosinophilia : implications for HIV/AIDS and co-endemic diseases

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dc.contributor.authorFincham, J. E.en
dc.contributor.authorMarkus, M. B.en
dc.contributor.authorAdams, V. J.en
dc.contributor.authorLombard, C. J.en
dc.contributor.authorBentwich, Z.en
dc.contributor.authorMansvelt, E. P. G.en
dc.contributor.authorDhansay, M. A.en
dc.contributor.authorSchoeman, S. E.en
dc.date.accessioned2011-05-15T15:55:18Z
dc.date.available2011-05-15T15:55:18Z
dc.date.issued2003-04
dc.descriptionPlease cite as follows:en
dc.descriptionFincham, J. E. et al. 2003. Association of deworming with reduced eosinophilia: Implications for HIV/AIDS and co-endemic diseases. South African Journal of Science , 99(3&4):182-184.en
dc.descriptionThe original publication is available at http://reference.sabinet.co.za.ez.sun.ac.za/document/EJC97605en
dc.description.abstractEosinophil counts in venous blood were monitored during a randomized controlled deworming trial (n = 155 children) that lasted for a year, and in a whole-school deworming programme (range 174-256 children) of 2 years' duration. Mean eosinophil counts (x109/I) decreased from 0.70 in the randomized trial, and 0.61 in the whole-school study, to well within the normal paediatric range of 0.05-0.45 (P < 0.05). The prevalence of eosinophilia declined from 57% to 37% in the randomized trial (mean for 400, 800 and 1200 mg albendazole doses); and from 47% to 24% in the whole-school study (500 mg stat mebendazole). Benzimidazole anthelminthics were highly effective against Ascaris but less so against Trichuris. Activated eosinophils are effector and immunoregulatory leucocytes of the T-helper cell type 2 (Th2) immune response to parasitic helminths and atopic disorders. Under conditions of poverty where soil-transmitted helminths are hyperendemic, Th2 polarization of the immune profile is characteristic. Regular anthelminthic treatment should reduce contact with worm antigens, and this may contribute to re-balancing of the immune profile. Suppression of eosinophil recruitment and activation, together with related cellular and molecular immunological changes, might have positive implications for prevention and treatment of co-endemic diseases, including HIV/AIDS, cholera, tuberculosis and atopic disorders.en
dc.description.versionPublishers' Version
dc.format.extent3 p.
dc.identifier.citationFincham, J. E. et al. 2003. Association of deworming with reduced eosinophilia: Implications for HIV/AIDS and co-endemic diseases. South African Journal of Science , 99(3&4):182-184.en
dc.identifier.issn1996-7489 (online)
dc.identifier.issn0038-2353 (print)
dc.identifier.urihttp://hdl.handle.net/10019.1/9699
dc.publisherAcademy of Science of South Africaen_ZA
dc.rights.holderAcademy of Science of South Africaen_ZA
dc.subjectDewormingen_ZA
dc.subjectEosinophilsen_ZA
dc.subjectHelminthsen_ZA
dc.titleAssociation of deworming with reduced eosinophilia : implications for HIV/AIDS and co-endemic diseasesen_ZA
dc.typeArticleen_ZA
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