Artemisia Spp. derivatives for COVID-19 treatment : anecdotal use, political hype, treatment potential, challenges, and road map to randomized clinical trials

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dc.contributor.authorKapepula, Paulin M.en_ZA
dc.contributor.authorKabengele, Jimmy K.en_ZA
dc.contributor.authorKingombe, Michelineen_ZA
dc.contributor.authorVan Bambeke, Francoiseen_ZA
dc.contributor.authorTulkens, Paul M.en_ZA
dc.contributor.authorKishabongo, Antoine Sadikien_ZA
dc.contributor.authorDecloedt, Ericen_ZA
dc.contributor.authorZumla, Adamen_ZA
dc.contributor.authorTiberi, Simonen_ZA
dc.contributor.authorSuleman, Fatimaen_ZA
dc.contributor.authorTshilolo, Leonen_ZA
dc.contributor.authorMuyembe-TamFum, Jean-Jacquesen_ZA
dc.contributor.authorZumla, Alimuddinen_ZA
dc.contributor.authorNachega, Jean B.en_ZA
dc.date.accessioned2020-08-31T13:35:48Z
dc.date.available2020-08-31T13:35:48Z
dc.date.issued2020
dc.descriptionCITATION: Kapepula, P. M. et al. 2020. Artemisia Spp. derivatives for COVID-19 treatment : anecdotal use, political hype, treatment potential, challenges, and road map to randomized clinical trials. American Journal of Tropical Medicine and Hygiene, doi:10.4269/ajtmh.20-0820.
dc.descriptionThe original publication is available at https://www.ajtmh.org
dc.description.abstractThe world is currently facing a novel COVID-19 pandemic caused by SARS-CoV-2 that, as of July 12, 2020, has caused a reported 12,322,395 cases and 556,335 deaths. To date, only two treatments, remdesivir and dexamethasone, have demonstrated clinical efficacy through randomized controlled trials (RCTs) in seriously ill patients. The search for new or repurposed drugs for treatment of COVID-19 continues. We have witnessed anecdotal use of herbal medicines, including Artemisia spp. extracts, in low-income countries, and exaggerated claims of their efficacies that are not evidence based, with subsequent political controversy. These events highlight the urgent need for further research on herbal compounds to evaluate efficacy through RCTs, and, when efficacious compounds are identified, to establish the active ingredients, develop formulations and dosing, and define pharmacokinetics, toxicology, and safety to enable drug development. Derivatives from the herb Artemisia annua have been used as traditional medicine over centuries for the treatment of fevers, malaria, and respiratory tract infections. We review the bioactive compounds, pharmacological and immunological effects, and traditional uses for Artemisia spp. derivatives, and discuss the challenges and controversies surrounding current efforts and the scientific road map to advance them to prevent or treat COVID-19.en_ZA
dc.description.urihttps://www.ajtmh.org/content/journals/10.4269/ajtmh.20-0820
dc.description.versionPublisher's version
dc.format.extent5 pages
dc.identifier.citationKapepula, P. M. et al. 2020. Artemisia Spp. derivatives for COVID-19 treatment : anecdotal use, political hype, treatment potential, challenges, and road map to randomized clinical trials. American Journal of Tropical Medicine and Hygiene, doi:10.4269/ajtmh.20-0820.
dc.identifier.issn1476-1645 (online)
dc.identifier.otherdoi:10.4269/ajtmh.20-0820
dc.identifier.urihttp://hdl.handle.net/10019.1/108770
dc.language.isoen_ZAen_ZA
dc.publisherAmerican Society of Tropical Medicine and Hygiene
dc.rights.holderAuthors retain copyright
dc.subjectCOVID-19 (Disease)en_ZA
dc.subjectArtemisiaen_ZA
dc.titleArtemisia Spp. derivatives for COVID-19 treatment : anecdotal use, political hype, treatment potential, challenges, and road map to randomized clinical trialsen_ZA
dc.typeArticleen_ZA
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