Backbone resonance assignments of the catalytic and regulatory domains of Ca2+/calmodulin-dependent protein kinase 1D

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dc.contributor.authorTong, Michael H. G.en_ZA
dc.contributor.authorJeeves, Marken_ZA
dc.contributor.authorRajesh, Sundaresanen_ZA
dc.contributor.authorLudwig, Christianen_ZA
dc.contributor.authorLenoir, Marcen_ZA
dc.contributor.authorKumar, Jitendraen_ZA
dc.contributor.authorMcClelland, Darren M.en_ZA
dc.contributor.authorBerditchevski, Fedoren_ZA
dc.contributor.authorHubbard, Julia A.en_ZA
dc.contributor.authorKenyon, Colinen_ZA
dc.contributor.authorButterworth, Samen_ZA
dc.contributor.authorKnapp, Stefanen_ZA
dc.contributor.authorOverduin, Michaelen_ZA
dc.date.accessioned2022-05-03T08:03:09Z
dc.date.available2022-05-03T08:03:09Z
dc.date.issued2020-06-13
dc.descriptionCITATION: Tong, Michael H. G. et al. 2020. Backbone resonance assignments of the catalytic and regulatory domains of Ca2+/calmodulin-dependent protein kinase 1D. Biomolecular NMR Assignments, 14:221–225, doi:10.1007/s12104-020-09950-x.en_ZA
dc.descriptionThe original publication is available at: https://www.ncbi.nlm.nih.gov
dc.description.abstractThe CaMK subfamily of Ser/Thr kinases are regulated by calmodulin interactions with their C-terminal regions. They are exemplified by Ca2+/calmodulin dependent protein kinase 1δ which is known as CaMK1D, CaMKIδ or CKLiK. CaMK1D mediates intracellular signalling downstream of Ca2+ influx and thereby exhibits amplifications of Ca2+signals and polymorphisms that have been implicated in breast cancer and diabetes. Here we report the backbone 1H, 13C, 15N assignments of the 38 kDa human CaMK1D protein in its free state, including both the canonical bi-lobed kinase fold as well as the autoinhibitory and calmodulin binding domains.en_ZA
dc.description.versionPublisher's version
dc.format.extent5 pages
dc.identifier.citationTong, Michael H. G. et al. 2020. Backbone resonance assignments of the catalytic and regulatory domains of Ca2+/calmodulin-dependent protein kinase 1D. Biomolecular NMR Assignments, 14:221–225, doi:10.1007/s12104-020-09950-xen_ZA
dc.identifier.otherdoi:10.1007/s12104-020-09950-x
dc.identifier.urihttp://hdl.handle.net/10019.1/125175
dc.language.isoen_ZAen_ZA
dc.publisherSpringer
dc.rights.holderAuthors retain copyright
dc.subjectprotein resonance assignmenten_ZA
dc.subjectNMRen_ZA
dc.subjectcalcium/calmodulin dependent protein kinaseen_ZA
dc.subjectCaMK1Den_ZA
dc.subjectCaMKIδen_ZA
dc.subjectCKLiKen_ZA
dc.titleBackbone resonance assignments of the catalytic and regulatory domains of Ca2+/calmodulin-dependent protein kinase 1Den_ZA
dc.typeArticleen_ZA
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