Child development, growth and microbiota : follow-up of a randomized education trial in Uganda

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dc.contributor.authorAtukunda, Prudenceen_ZA
dc.contributor.authorMuhoozi, Grace K. M.en_ZA
dc.contributor.authorVan Den Broek, Tim J.en_ZA
dc.contributor.authorKort, Remcoen_ZA
dc.contributor.authorDiep, Lien M.en_ZA
dc.contributor.authorKaaya, Archileo N.en_ZA
dc.contributor.authorIversen, Per O.en_ZA
dc.contributor.authorWesterberg, Ane C.en_ZA
dc.date.accessioned2021-10-15T10:44:11Z
dc.date.available2021-10-15T10:44:11Z
dc.date.issued2019
dc.descriptionCITATION: Atukunda, P., et al. 2019. Child development, growth and microbiota : follow-up of a randomized education trial in Uganda. Journal of Global Health, 9(1):010431, doi:10.7189/jogh.09.010431.
dc.descriptionThe original publication is available at http://jogha.org
dc.description.abstractBackground: Undernutrition impairs child development outcomes and growth. In this follow-up study of an open cluster-randomized intervention trial we examined the effects of an education package delivered to mothers in rural Uganda on their children’s development, growth and gut microbiota at 36 months of age. Methods: The parental trial included 511 mother-child pairs recruited when the children were 6-8 months. In that trial, a nutrition, stimulation and hygiene education was delivered to mothers in the intervention group while the control group received routine health care. A follow-up sample of 155 pairs (intervention n = 77, control n = 78) were re-enrolled when the children were 24 months. Developmental outcomes were assessed with the Bayley Scales of Infant and Toddler Development (BSID-III) composite scores for cognitive (primary endpoint), language and motor development. Development outcomes were also evaluated using the Ages and Stages Questionnaire (ASQ) and the Mullen Scales of Early Learning (MSEL). Other outcomes included growth and gut microbiota composition. Results: The demographic characteristics were not different (P > 0.05) between the intervention and control groups and similar to those of the parental study. The intervention group had higher BSID-III scores than controls, with mean difference 10.13 (95% confidence interval (CI): 3.31-17.05, P = 0.002); 7.59 (1.62-13.66, P = 0.01); 9.00 (2.92-15.40, P = 0.005), for cognitive, language and motor composite scores, respectively. An improvement in the intervention compared to the control group was obtained for both the ASQ and the MSEL scores. The mean difference in height-for-age z-score was higher in the intervention compared to the control group: 0.50 (0.25-0.75, P = 0.0001). Gut microbiota composition did not differ significantly between the two study groups. Conclusions: The maternal education intervention had positive effects on child development and growth at three years, but did not alter gut microbiota composition. This intervention may be applicable in other low-resource settings.en_ZA
dc.description.urihttp://jogha.org/documents/issue201901/jogh-09-010431.htm
dc.description.versionPublisher's version
dc.format.extent11 pages ; illustrations
dc.identifier.citationAtukunda, P., et al. 2019. Child development, growth and microbiota : follow-up of a randomized education trial in Uganda. Journal of Global Health, 9(1):010431, doi:10.7189/jogh.09.010431
dc.identifier.issn2047-2986 (online)
dc.identifier.issn2047-2978 (print)
dc.identifier.otherdoi:10.7189/jogh.09.010431
dc.identifier.urihttp://hdl.handle.net/10019.1/123236
dc.language.isoen_ZAen_ZA
dc.publisherInternational Society of Global Health
dc.rights.holderAuthors retain copyright
dc.subjectHealth education of women -- Ugandaen_ZA
dc.subjectChild development -- Ugandaen_ZA
dc.subjectChildren -- Growth -- Ugandaen_ZA
dc.subjectMicroorganisms -- Ugandaen_ZA
dc.subjectClinical trials -- Ugandaen_ZA
dc.titleChild development, growth and microbiota : follow-up of a randomized education trial in Ugandaen_ZA
dc.typeArticleen_ZA
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