Experimental Mycobacterium bovis infection in three white rhinoceroses (Ceratotherium simum) : Susceptibility, clinical and anatomical pathology

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dc.contributor.authorMichel, Anita L.en_ZA
dc.contributor.authorLane, Emily P.en_ZA
dc.contributor.authorDe Klerk-Lorist, Lin-Marien_ZA
dc.contributor.authorHofmeyr, Markusen_ZA
dc.contributor.authorVan Der Heijden, Elisabeth M. D. L.en_ZA
dc.contributor.authorBotha, Louiseen_ZA
dc.contributor.authorVan Helden, Paulen_ZA
dc.contributor.authorMiller, Michele Annen_ZA
dc.contributor.authorBuss, Peter E.en_ZA
dc.date.accessioned2019-02-25T08:12:23Z
dc.date.available2019-02-25T08:12:23Z
dc.date.issued2017
dc.descriptionCITATION: Michel, A. L., et al. 2017. Experimental Mycobacterium bovis infection in three white rhinoceroses (Ceratotherium simum) : Susceptibility, clinical and anatomical pathology. PLoS ONE, 12(7):e0179943, doi:10.1371/journal.pone.0179943.
dc.descriptionThe original publication is available at https://journals.plos.org/plosone
dc.description.abstractTuberculosis caused by Mycobacterium bovis is endemic in the African buffalo (Syncerus caffer) population in the Kruger National Park and other conservation areas in South Africa. The disease has been diagnosed in a total of 21 free ranging or semi-free ranging wildlife species in the country with highly variable presentations in terms of clinical signs as well as severity and distribution of tuberculous lesions. Most species are spillover or dead-end hosts without significant role in the epidemiology of the disease. White rhinoceroses (Ceratotherium simum) are translocated from the Kruger National Park in substantial numbers every year and a clear understanding of their risk to manifest overt tuberculosis disease and to serve as source of infection to other species is required. We report the findings of experimental infection of three white rhinoceroses with a moderately low dose of a virulent field isolate of Mycobacterium bovis. None of the animals developed clinical signs or disseminated disease. The susceptibility of the white rhinoceros to bovine tuberculosis was confirmed by successful experimental infection based on the ante mortem isolation of M. bovis from the respiratory tract of one rhinoceros, the presence of acid-fast organisms and necrotizing granulomatous lesions in the tracheobronchial lymph nodes and the detection of M. bovis genetic material by PCR in the lungs of two animals.en_ZA
dc.description.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0179943
dc.description.versionPublisher's version
dc.format.extent16 pages
dc.identifier.citationMichel, A. L., et al. 2017. Experimental Mycobacterium bovis infection in three white rhinoceroses (Ceratotherium simum) : Susceptibility, clinical and anatomical pathology. PLoS ONE, 12(7):e0179943, doi:10.1371/journal.pone.0179943
dc.identifier.issn1932-6203 (online)
dc.identifier.otherdoi:10.1371/journal.pone.0179943
dc.identifier.urihttp://hdl.handle.net/10019.1/105465
dc.language.isoen_ZAen_ZA
dc.publisherPublic Library of Science
dc.rights.holderAuthors retain copyright
dc.subjectMycobacterium tuberculosisen_ZA
dc.titleExperimental Mycobacterium bovis infection in three white rhinoceroses (Ceratotherium simum) : Susceptibility, clinical and anatomical pathologyen_ZA
dc.typeArticleen_ZA
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