Prenatal diagnosis of chromosomal abnormalities in a resource-poor setting

Simple item page
dc.contributor.authorGeerts L.
dc.date.accessioned2011-05-15T16:16:41Z
dc.date.available2011-05-15T16:16:41Z
dc.date.issued2008
dc.description.abstractObjective: To compare the efficacy and efficiency of systematic, ultrasound-based risk adjustment using a published algorithm with that of a maternal age cutoff of 37 years for the prenatal detection of chromosomal abnormalities (especially autosomal trisomies). Methods: These approaches were compared in a retrospective study of 136 chromosomal abnormalities confirmed by karyotyping prenatally (n = 46) or postnatally (n = 90). There were 114 autosomal trisomies. Results: Maternal age was known for 103 fetuses with confirmed abnormalities. The ultrasound-based risk adjustment approach was more sensitive for autosomal trisomy (93.9% vs 44.1%), and karyotyping for younger women with abnormalities on ultrasound was more effective than routine karyotyping in older women (1 trisomy detected in 13.5 vs 42.8 samples, P < 0.001). A lack of screening was the main reason for the postnatal diagnosis. Conclusion: Ultrasound-based risk adjustment was the more effective approach. © 2008 International Federation of Gynecology and Obstetrics.
dc.description.versionArticle
dc.identifier.citationInternational Journal of Gynecology and Obstetrics
dc.identifier.citation103
dc.identifier.citation1
dc.identifier.issn00207292
dc.identifier.other10.1016/j.ijgo.2008.05.028
dc.identifier.urihttp://hdl.handle.net/10019.1/13891
dc.subjectarticle
dc.subjectchromosome aberration
dc.subjectconception
dc.subjectcontrolled study
dc.subjecthuman
dc.subjectkaryotyping
dc.subjectmaternal age
dc.subjectprenatal diagnosis
dc.subjectpriority journal
dc.subjectrisk assessment
dc.subjectscreening
dc.subjecttrisomy
dc.subjectultrasound
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAge Factors
dc.subjectAlgorithms
dc.subjectChromosome Disorders
dc.subjectFemale
dc.subjectHealth Services Accessibility
dc.subjectHumans
dc.subjectKaryotyping
dc.subjectMiddle Aged
dc.subjectPregnancy
dc.subjectRetrospective Studies
dc.subjectRisk Adjustment
dc.subjectSensitivity and Specificity
dc.subjectTrisomy
dc.subjectUltrasonography, Prenatal
dc.subjectYoung Adult
dc.titlePrenatal diagnosis of chromosomal abnormalities in a resource-poor setting
dc.typeArticle
Files
Collections
Stellenbosch University - Scopus Tygerberg Hospital Publications