Negative association of MC3R variants with weight and blood pressure in Cape Town pupils aged 11 - 16 years

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dc.contributor.authorYako, Y. Y.en_ZA
dc.contributor.authorFanampe, B. L.en_ZA
dc.contributor.authorHassan, S. M.en_ZA
dc.contributor.authorErasmus, R. T.en_ZA
dc.contributor.authorVan der Merwe, L.en_ZA
dc.contributor.authorMatsha, T. E.en_ZA
dc.date.accessioned2011-10-13T16:59:07Z
dc.date.available2011-10-13T16:59:07Z
dc.date.issued2011-06
dc.descriptionThe original publication is available at http://www.samj.org.zaen_ZA
dc.description.abstractBackground. Human and animal studies support the role of MC4R and MC3R in human obesity, but limited data are available on the genetic contribution to obesity in South African populations. Objective. To screen obese-overweight South African pupils for MC3R and MC4R polymorphisms that may play a role in the development of obesity. Design. A cross-sectional study screened 227 obese-overweight (115 black and 112 coloured) and 204 normal weight (94 black, 110 coloured) school pupils for the presence of MC4R and MC3R polymorphisms using a single strand conformation polymorphism, subsequent sequencing, and allele specific restriction enzyme analysis. Results. Two polymorphisms were detected in the MC3R (T6K and V81I) but none in MC4R. After adjusting for age, gender and case-control status, the frequency distributions of T6K and V81I genotype and allele varied significantly between the ethnic groups. The frequency of the V81I A allele was significantly lower in coloured overweight-obesity than normal pupils. In coloured pupils, both polymorphisms were associated with obesity indices and total cholesterol. The T6K A allele was also associated with lower blood pressure. Likewise, different T6K-V81I haplotypes demonstrated negative associations with obesity indices and blood pressure. Conclusion. We demonstrated that the MC3R polymorphisms have a protective effect on metabolic traits; however, further analysis is required to confirm whether this translates to a lower incidence of metabolic syndrome in coloured populations.en_ZA
dc.description.versionPublishers’ version
dc.format.extentpp. 417-420
dc.identifier.citationYako, Y. Y. et al. 2011. Negative association of MC3R variants with weight and blood pressure in Cape Town pupils aged 11 - 16 years. South African Medical Journal, 101(6):417-420.en_ZA
dc.identifier.issn2078-5135 (online)
dc.identifier.issn0256-9574 (print)
dc.identifier.urihttp://hdl.handle.net/10019.1/16985
dc.language.isoen_ZA
dc.publisherHealth and Medical Publishing Group (HMPG)en_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectObesity in adolescence -- South Africa -- Cape Town -- Genetic aspectsen_ZA
dc.subjectNutrition disorders in adolescence -- Genetic aspectsen_ZA
dc.subjectGenetic polymorphisms -- South Africa -- Cape Town -- Cross-cultural studiesen_ZA
dc.subjectHypertension in adolescence -- South Africa -- Cape Town -- Genetic aspects -- Cross-cultural studiesen_ZA
dc.subject.lcshObesity in adolescence -- South Africa -- Cape Town -- Cross-cultural studiesen_ZA
dc.titleNegative association of MC3R variants with weight and blood pressure in Cape Town pupils aged 11 - 16 yearsen_ZA
dc.typeArticleen_ZA
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