Rooting the phylogenetic tree of Middle East respiratory syndrome coronavirus by characterization of a conspecific virus from an African bat

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dc.contributor.authorCorman, V. M.en_ZA
dc.contributor.authorIthete, Ndapewa L.en_ZA
dc.contributor.authorRichards, L. R.en_ZA
dc.contributor.authorSchoeman, M. C.en_ZA
dc.contributor.authorPreiser, Wolfgangen_ZA
dc.contributor.authorDrosten, C.en_ZA
dc.contributor.authorDrexler, J. F.en_ZA
dc.contributor.otherPathology: Medical Virologyen_ZA
dc.date.accessioned2016-07-11T12:47:45Z
dc.date.available2016-07-11T12:47:45Z
dc.date.issued2014-10
dc.descriptionCITATION: Corman, V. M. et al. 2014. Rooting the phylogenetic tree of middle East respiratory syndrome coronavirus by characterization of a conspecific virus from an African bat. Journal of Virology. 88(19):11297-303. doi: 10.1128/JVI.01498-14.en_ZA
dc.descriptionThe original publication is available at http://jvi.asm.orgen_ZA
dc.description.abstractThe emerging Middle East respiratory syndrome coronavirus (MERS-CoV) causes lethal respiratory infections mainly on the Arabian Peninsula. The evolutionary origins of MERS-CoV are unknown. We determined the full genome sequence of a CoV directly from fecal material obtained from a South African Neoromicia capensis bat (NeoCoV). NeoCoV shared essential details of genome architecture with MERS-CoV. Eighty-five percent of the NeoCoV genome was identical to MERS-CoV at the nucleotide level. Based on taxonomic criteria, NeoCoV and MERS-CoV belonged to one viral species. The presence of a genetically divergent S1 subunit within the NeoCoV spike gene indicated that intraspike recombination events may have been involved in the emergence of MERS-CoV. NeoCoV constitutes a sister taxon of MERS-CoV, placing the MERS-CoV root between a recently described virus from African camels and all other viruses. This suggests a higher level of viral diversity in camels than in humans. Together with serologic evidence for widespread MERS-CoV infection in camelids sampled up to 20 years ago in Africa and the Arabian Peninsula, the genetic data indicate that camels act as sources of virus for humans rather than vice versa. The majority of camels on the Arabian Peninsula is imported from the Greater Horn of Africa, where several Neoromicia species occur. The acquisition of MERS-CoV by camels from bats might have taken place in sub-Saharan Africa. Camelids may represent mixing vessels for MERS-CoV and other mammalian CoVs.en_ZA
dc.description.urihttp://jvi.asm.org/content/88/19/11297.longen_ZA
dc.description.versionPublisher's versionen_ZA
dc.format.extent7 pages
dc.identifier.citationCorman, V. M. et al. 2014. Rooting the phylogenetic tree of middle East respiratory syndrome coronavirus by characterization of a conspecific virus from an African bat. Journal of Virology. 88(19):11297-303. doi: 10.1128/JVI.01498-14.en_ZA
dc.identifier.issn1098-5514 (online)
dc.identifier.issn0022-538X (print)
dc.identifier.otherdoi: 10.1128/JVI.01498-14
dc.identifier.urihttp://hdl.handle.net/10019.1/99128
dc.language.isoen_ZAen_ZA
dc.publisherAmerican Society for Microbiologyen_ZA
dc.rights.holderAmerican Society for Microbiologyen_ZA
dc.subjectCoronavirus infectionsen_ZA
dc.subjectCoronavirusesen_ZA
dc.subjectBats -- Phylogenyen_ZA
dc.titleRooting the phylogenetic tree of Middle East respiratory syndrome coronavirus by characterization of a conspecific virus from an African baten_ZA
dc.typeArticleen_ZA
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