Evaluation of drug interaction potential of Labisia pumila (Kacip Fatimah) and its constituents

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dc.contributor.authorManda, Vamshi K.en_ZA
dc.contributor.authorDale, Olivia R.en_ZA
dc.contributor.authorAwortwe, Charlesen_ZA
dc.contributor.authorAli, Zulfiqaren_ZA
dc.contributor.authorKhan, Ikhlas A.en_ZA
dc.contributor.authorWalker, Larry A.en_ZA
dc.contributor.authorKhan, Shabana I.en_ZA
dc.date.accessioned2017-01-30T09:33:04Z
dc.date.available2017-01-30T09:33:04Z
dc.date.issued2014-08-08
dc.descriptionCITATION: Manda, V. K. et al. 2014. Evaluation of drug interaction potential of Labisia pumila (Kacip Fatimah) and its constituents. Frontiers in Pharmacology, 5:178, doi:10.3389/fphar.2014.00178.
dc.descriptionThe original publication is available at http://journal.frontiersin.org/journal/pharmacology
dc.description.abstractENGLISH ABSTRACT: Labisia pumila (Kacip Fatimah) is a popular herb in Malaysia that has been traditionally used in a number of women’s health applications such as to improve libido, relieve postmenopausal symptoms, and to facilitate or hasten delivery in childbirth. In addition, the constituents of this plant have been reported to possess anticancer, antioxidant, and anti-inflammatory properties. Clinical studies have indicated that cytochrome P450s (CYPs), P-glycoprotein (P-gp), and Pregnane X receptor (PXR) are the three main modulators of drug-drug interactions which alter the absorption, distribution, and metabolism of drugs. Given the widespread use of Kacip Fatimah in dietary supplements, the current study focuses on determining the potential of its constituents to affect the activities of CYPs, P-gp, or PXR using in vitro assays which may provide useful information toward the risk of herb-drug interaction with concomitantly used drugs. Six compounds isolated from the roots of L. pumila (2 saponins and 4 alkyl phenols) were tested, in addition to the methanolic extract. The extract of L. pumila showed a significant time dependent inhibition (TDI) of CYP3A4, reversible inhibition of CYP2C9 and 2C19 and a weak inhibition of 1A2 and 2D6 as well as an inhibition of P-gp and rifampicin-induced PXR activation. The alkyl phenols inhibited CYP3A4 (TDI), CYP2C9, and 2C19 (reversible) while saponins inhibited P-gp and PXR. In conclusion, L. pumila and its constituents showed significant modulation of all three regulatory proteins (CYPs, P-gp, and PXR) suggesting a potential to alter the pharmacokinetic and pharmacodynamic properties of conventional drugs if used concomitantly.en_ZA
dc.description.abstractAFRIKAANSE OPSOMMING: Geen opsomming beskikbaaraf_ZA
dc.description.urihttp://journal.frontiersin.org/article/10.3389/fphar.2014.00178/full
dc.description.versionPublisher's version
dc.format.extent13 pagesen_ZA
dc.identifier.citationManda, V. K. et al. 2014. Evaluation of drug interaction potential of Labisia pumila (Kacip Fatimah) and its constituents. Frontiers in Pharmacology, 5:178, doi:10.3389/fphar.2014.00178.
dc.identifier.issn1663-9812 (online)
dc.identifier.otherdoi:10.3389/fphar.2014.00178
dc.identifier.urihttp://hdl.handle.net/10019.1/100557
dc.language.isoen_ZAen_ZA
dc.publisherFrontiers
dc.rights.holderAuthors retain copyright
dc.subjectLabisia pumilaen_ZA
dc.subjectMyrsinaceaeen_ZA
dc.subjectHerb-drug interactionsen_ZA
dc.titleEvaluation of drug interaction potential of Labisia pumila (Kacip Fatimah) and its constituentsen_ZA
dc.typeArticleen_ZA
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