Bladder cancer histological variants: which parameters could predict the concordance between transurethral resection of bladder tumor and radical cystectomy specimens?

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dc.contributor.authorMantica, Guglielmoen_ZA
dc.contributor.authorTappero, Stefanoen_ZA
dc.contributor.authorParodi, Stefanoen_ZA
dc.contributor.authorPiol, Natanieleen_ZA
dc.contributor.authorSpina, Brunoen_ZA
dc.contributor.authorMalinaric, Rafaelaen_ZA
dc.contributor.authorBalzarini, Federicaen_ZA
dc.contributor.authorBorghesi, Marcoen_ZA
dc.contributor.authorVan der Merwe, Andréen_ZA
dc.contributor.authorSuardi, Nazarenoen_ZA
dc.contributor.authorTerrone, Carloen_ZA
dc.date.accessioned2023-05-11T10:12:00Zen_ZA
dc.date.available2023-05-11T10:12:00Zen_ZA
dc.date.issued2021-09en_ZA
dc.descriptionCITATION: Mantica G, Tappero S, Parodi S, et al. 2021. Bladder cancer histological variants: which parameters could predict the concordance between transurethral resection of bladder tumor and radical cystectomy specimens? Cent European J Urol. doi.10.5173/ceju.2021.140.R1en_ZA
dc.descriptionThe original publication is available at: ceju.onlineen_ZA
dc.description.abstractIntroduction The concordance rate of bladder cancer (BCa) histological variants (HV) between transurethral resection of bladder tumor (TURBT) and radical cystectomy (RC) is sub-optimal and is unclear which factors may influence it. The aim of this study was to identify factors that may be correlated to a higher TURBT-RC concordance rate. Material and methods Consecutive patients who had undergone RC between 2000 and 2019 at a single Institution with pathological evidence of HV were included. Patients with diagnosis of HV both at RC and at the previous TURBT were enlisted in the TURBT-RC Concordance Group (CG), whereas patients with only evidence of HV at RC in the TURBT-RC Non-Concordance Group (NCG). Surgical factors evaluated were the source of energy (mono- vs bipolar), surgeon’s experience (</≥100), execution of re-TURBT, number and size of specimens at TURBT. Results A total of 81 patients were included, 49 (60.5%) in the CG and 32 (39.5%) in the NCG. Among the surgical factors, maximal core length (MCL) was significantly higher in the CG (12.5 vs. 10 mm, p = 0.014) (Table 1). At uni- and multivariable analyses, MCL >10 mm represented an independent predictor of cornd-ance [OR 2.95; CI (1.01–8.61); p = 0.048]. Tumor recurrence, focality and dimension, source of energy, surgeon’s experience, performance of re-TURBT and total number of specimens at TURBT did not significantly predict the concordance. Conclusions Longer specimens at TURBT yield a higher chance to detect HV before RC. In this light, improving the quality of bladder resection means improving the management of BCa.en_ZA
dc.description.versionPublisher’s versionen_ZA
dc.format.extent7 pagesen_ZA
dc.identifier.issn2080-4873 (online)en_ZA
dc.identifier.otherdoi.10.5173/ceju.2021.140.R1en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/126899en_ZA
dc.language.isoen_ZAen_ZA
dc.publisherUrological Associationen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectBladder -- Cancer -- Diagnosisen_ZA
dc.subjectUrinary organs -- Cancer -- Diagnosisen_ZA
dc.subjectBladder -- Cancer -- Treatmenten_ZA
dc.subjectUrinary organs -- Cancer -- Treatmenten_ZA
dc.subjectUrothelial bladder canceren_ZA
dc.titleBladder cancer histological variants: which parameters could predict the concordance between transurethral resection of bladder tumor and radical cystectomy specimens?en_ZA
dc.typeArticleen_ZA
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