Cerebrospinal fluid alpha-1-antitrypsin alpha-1-antitrypsin-elastase complex levels in meningitis

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dc.contributor.authorDu Hoffman P.H.
dc.contributor.authorDonald P.R.
dc.contributor.authorHanekom C.
dc.contributor.authorDe Beer F.C.
dc.date.accessioned2011-05-15T16:16:19Z
dc.date.available2011-05-15T16:16:19Z
dc.date.issued1989
dc.description.abstractAlpha-1-antitrypsin (A-1-AT) and A-1-AT-elastase complex levels in cerebrospinal fluid have been evaluated in 11 children with viral meningitis (VM), 14 with bacterial meningitis (BM), 10 with tuberculous meningitis (TBM) and 10 investigated for, but found not to have meningitis (NM). A-1-AT concentrations in the NM group were lower than in the BM group (P = 0.0002) and the TBM group (P = 0.0005) but did not differ from the concentrations in VM; those in the VM group were lower than in the BM group (P = 0.0001) and the TBM group (P = 0.003) but no difference was found between the BM and TBM groups. A-1-AT-elastase complex concentrations in CSF were lower in the NM group than the BM group (P = 0.0001) or the TBM group (P = 0.0089), however those in the BM group were significantly higher than in the TBM group (P = 0.0001). A significant correlation existed in CSF between the protein concentrations and neutrophil counts as well as the A-1-AT and A-1-AT-elastase complex concentrations.
dc.description.versionArticle
dc.identifier.citationEuropean Journal of Clinical Investigation
dc.identifier.citation19
dc.identifier.citation1
dc.identifier.issn00142972
dc.identifier.urihttp://hdl.handle.net/10019.1/13729
dc.subjectalpha 1 antitrypsin
dc.subjectelastase
dc.subjectbacterial meningitis
dc.subjectcerebrospinal fluid level
dc.subjectchild
dc.subjectclinical article
dc.subjecthuman
dc.subjectmeningitis
dc.subjectpriority journal
dc.subjecttuberculous meningitis
dc.subjectvirus meningitis
dc.subjectAdolescent
dc.subjectalpha 1-Antitrypsin
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectEnterovirus Infections
dc.subjectHaemophilus influenzae
dc.subjectHuman
dc.subjectImmunoelectrophoresis
dc.subjectInfant
dc.subjectMeningitis
dc.subjectMeningitis, Haemophilus
dc.subjectMeningitis, Meningococcal
dc.subjectMeningitis, Pneumococcal
dc.subjectMeningitis, Viral
dc.subjectPancreatic Elastase
dc.subjectStreptococcal Infections
dc.subjectStreptococcus agalactiae
dc.subjectSupport, Non-U.S. Gov't
dc.subjectTuberculosis, Meningeal
dc.titleCerebrospinal fluid alpha-1-antitrypsin alpha-1-antitrypsin-elastase complex levels in meningitis
dc.typeArticle
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