Bacteria of the genus xenorhabdus, a novel source of bioactive compounds

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dc.contributor.authorDreyer, Jonikeen_ZA
dc.contributor.authorMalan, Antoinette P.en_ZA
dc.contributor.authorDicks, Leon Milner Theodore, 1961-en_ZA
dc.date.accessioned2019-01-10T07:05:08Z
dc.date.available2019-01-10T07:05:08Z
dc.date.issued2018-12-19
dc.descriptionCITATION: Dreyer, J., Malan, A. P. & Dicks, L. M. T. 2018. Bacteria of the genus xenorhabdus, a novel source of bioactive compounds. Frontiers in Microbiology, 9:3177, doi:10.3389/fmicb.2018.03177.en_ZA
dc.descriptionThe original publication is available at https://www.frontiersin.orgen_ZA
dc.descriptionPublication of this article was funded by the Stellenbosch University Open Access Fund.en_ZA
dc.description.abstractThe genus Xenorhabdus of the family Enterobacteriaceae, are mutualistically associated with entomopathogenic nematodes of the genus Steinernema. Although most of the associations are species-specific, a specific Xenorhabdus sp. may infect more than one Steinernema sp. During the Xenorhabdus–Steinernema life cycle, insect larvae are infected and killed, while both mutualists produce bioactive compounds. These compounds act synergistically to ensure reproduction and proliferation of the nematodes and bacteria. A single strain of Xenorhabdus may produce a variety of antibacterial and antifungal compounds, some of which are also active against insects, nematodes, protozoa, and cancer cells. Antimicrobial compounds produced by Xenorhabdus spp. have not been researched to the same extent as other soil bacteria and they may hold the answer to novel antibacterial and antifungal compounds. This review summarizes the bioactive secondary metabolites produced by Xenorhabdus spp. and their application in disease control. Gene regulation and increasing the production of a few of these antimicrobial compounds are discussed. Aspects limiting future development of these novel bioactive compounds are also pointed out.en_ZA
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fmicb.2018.03177/full
dc.description.versionPublisher's versionen_ZA
dc.format.extent14 pages : illustrationsen_ZA
dc.identifier.citationDreyer, J., Malan, A. P. & Dicks, L. M. T. 2018. Bacteria of the genus xenorhabdus, a novel source of bioactive compounds. Frontiers in Microbiology, 9:3177, doi:10.3389/fmicb.2018.03177en_ZA
dc.identifier.issn1664-302X (online)
dc.identifier.otherdoi:10.3389/fmicb.2018.03177
dc.identifier.urihttp://hdl.handle.net/10019.1/105287
dc.language.isoen_ZAen_ZA
dc.publisherFrontiers Mediaen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectXenorhabdusen_ZA
dc.subjectBioactive compoundsen_ZA
dc.subjectAntimicrobial compounds -- Productionen_ZA
dc.subjectPeptide antibioticsen_ZA
dc.titleBacteria of the genus xenorhabdus, a novel source of bioactive compoundsen_ZA
dc.typeArticleen_ZA
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