Evidence of neuroinflammation and blood–brain barrier disruption in women with preeclampsia and eclampsia

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dc.contributor.authorBergman, Linaen_ZA
dc.contributor.authorHastie, Roxanneen_ZA
dc.contributor.authorZetterberg, Henriken_ZA
dc.contributor.authorBlennow, Kajen_ZA
dc.contributor.authorSchell, Sonjaen_ZA
dc.contributor.authorLangenegger, Eduarden_ZA
dc.contributor.authorMoodley, Ashleyen_ZA
dc.contributor.authorWalker, Susanen_ZA
dc.contributor.authorTong, Stephenen_ZA
dc.contributor.authorCluver, Catherineen_ZA
dc.date.accessioned2022-01-04T09:20:17Z
dc.date.available2022-01-04T09:20:17Z
dc.date.issued2021-11-05
dc.descriptionCITATION: Bergman, L. et al. 2021. Evidence of neuroinflammation and blood–brain barrier disruption in women with preeclampsia and eclampsia. Cells, 10(11):3045, doi:10.3390/cells10113045.
dc.descriptionThe original publication is available at https://www.mdpi.com
dc.description.abstractENGLISH ABSTRACT: Cerebral complications in preeclampsia are leading causes of maternal mortality. Animal models suggest that an injured blood–brain barrier and neuroinflammation may be important but there is paucity of data from human studies. Therefore, we aimed to evaluate this in women with preeclampsia and eclampsia. We included women recruited to the South African Preeclampsia Obstetric Adverse Events (PROVE) biobank. Blood and cerebrospinal fluid (CSF) were collected around delivery. CSF was analyzed for neuroinflammatory markers interleukin 1β, interleukin 6, interleukin-8 and tumor necrosis factor alpha (TNF-alpha). The CSF to plasma albumin ratio was measured to assess blood–brain barrier function. Women with eclampsia (n = 4) showed increased CSF concentrations of all pro-inflammatory cytokines and TNF-alpha compared to women with normotensive pregnancies (n = 7) and also for interleukin-6 and TNF-alpha compared to women with preeclampsia (n = 4). Women with preeclampsia also showed increases in pro-inflammatory cytokines IL-6 and IL-8 but not TNF-alpha in the CSF compared to women with normotensive pregnancies. In particular, women with eclampsia but also women with preeclampsia showed an increase in the CSF to plasma albumin ratio compared to normotensive women. In conclusion, women with preeclampsia and eclampsia show evidence of neuroinflammation and an injured blood–brain barrier. These findings are seen in particular among women with eclampsia.en_ZA
dc.description.urihttps://www.mdpi.com/2073-4409/10/11/3045
dc.description.versionPublisher's version
dc.format.extent11 pagesen_ZA
dc.identifier.citationBergman, L. et al. 2021. Evidence of neuroinflammation and blood–brain barrier disruption in women with preeclampsia and eclampsia. Cells, 10(11):3045, doi:10.3390/cells10113045.
dc.identifier.issn2073-4409 (online)
dc.identifier.otherdoi:10.3390/cells10113045
dc.identifier.urihttp://hdl.handle.net/10019.1/124037
dc.language.isoen_ZAen_ZA
dc.publisherMDPIen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectNeuroinflammationen_ZA
dc.subjectEclampsiaen_ZA
dc.subjectPreeclampsiaen_ZA
dc.subjectCerebral edemaen_ZA
dc.titleEvidence of neuroinflammation and blood–brain barrier disruption in women with preeclampsia and eclampsiaen_ZA
dc.typeArticleen_ZA
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