Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa : a retrospective cohort analysis

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dc.contributor.authorBouton, Tara C.en_ZA
dc.contributor.authorDe Vos, Margarethaen_ZA
dc.contributor.authorRagan, Elizabeth J.en_ZA
dc.contributor.authorWhite, Laura F.en_ZA
dc.contributor.authorVan Zyl, Leonieen_ZA
dc.contributor.authorTheron, Danieen_ZA
dc.contributor.authorHorsburgh, C. Roberten_ZA
dc.contributor.authorWarren, Robin M.en_ZA
dc.contributor.authorJacobson, Karen R.en_ZA
dc.date.accessioned2021-10-25T06:31:03Z
dc.date.available2021-10-25T06:31:03Z
dc.date.issued2019-10-17
dc.descriptionCITATION: Bouton, T. C., et al. 2019. Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa : a retrospective cohort analysis. PLoS ONE, 14(10). doi:10.1371/journal.pone.0223308
dc.descriptionThe original publication is available at https://journals.plos.org/plosone/
dc.description.abstractENGLISH ABSTRACT: South Africa led the world with guidelines on bedaquiline (BDQ) use as a single drug substitution to manage rifampin resistant tuberculosis regimen toxicity. We examined reasons for giving BDQ in a retrospective cohort: >75% of patients were switched to BDQ for toxicity (ototoxicity or renal dysfunction) rather than drug resistance.en_ZA
dc.description.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0223308
dc.description.versionPublisher's version
dc.format.extent6 pagesen_ZA
dc.identifier.citationBouton, T. C., et al. 2019. Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa : a retrospective cohort analysis. PLoS ONE, 14(10). doi:10.1371/journal.pone.0223308
dc.identifier.issn1932-6203 (online)
dc.identifier.otherdoi:10.1371/journal.pone.0223308
dc.identifier.urihttp://hdl.handle.net/10019.1/123284
dc.language.isoen_ZAen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.rights.holderAuthors retain rightsen_ZA
dc.subjectTuberculosis -- Treatmenten_ZA
dc.subjectBedaquiline (BDQ)en_ZA
dc.subjectAntibioticsen_ZA
dc.subjectRifampicinen_ZA
dc.subjectMultidrug-resistant tuberculosisen_ZA
dc.titleSwitching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa : a retrospective cohort analysisen_ZA
dc.typeArticleen_ZA
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