Multiple introductions of mycobacterium tuberculosis lineage 2–Beijing into Africa over centuries

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dc.contributor.authorRutaihwa, Liliana K.en_ZA
dc.contributor.authorMenardo, Fabrizioen_ZA
dc.contributor.authorStucki, Daviden_ZA
dc.contributor.authorGygli, Sebastian M.en_ZA
dc.contributor.authorLey, Serej D.en_ZA
dc.contributor.authorMalla, Bijayaen_ZA
dc.contributor.authorFeldmann, Juliaen_ZA
dc.contributor.authorBorrell, Soniaen_ZA
dc.contributor.authorBeisel, Christianen_ZA
dc.contributor.authorMiddelkoop, Kerrenen_ZA
dc.contributor.authorCarter, E. Janeen_ZA
dc.contributor.authorDiero, Lamecken_ZA
dc.contributor.authorBallif, Marieen_ZA
dc.contributor.authorJugheli, Levanen_ZA
dc.contributor.authorReither, Klausen_ZA
dc.contributor.authorFenner, Lukasen_ZA
dc.contributor.authorBrites, Danielaen_ZA
dc.contributor.authorGagneux, Sebastienen_ZA
dc.date.accessioned2021-11-04T09:17:09Z
dc.date.available2021-11-04T09:17:09Z
dc.date.issued2019
dc.descriptionCITATION: Rutaihwa, L. K. 2019. Multiple introductions of mycobacterium tuberculosis lineage 2–Beijing into Africa over centuries. Frontiers in Ecology and Evolution, 7:112, doi:10.3389/fevo.2019.00112.
dc.descriptionThe original publication is available at http://journal.frontiersin.org/journal/ecology-and-evolution
dc.description.abstractENGLISH ABSTRACT: The Lineage 2–Beijing (L2–Beijing) sub-lineage of Mycobacterium tuberculosis has received much attention due to its high virulence, fast disease progression, and association with antibiotic resistance. Despite several reports of the recent emergence of L2–Beijing in Africa, no study has investigated the evolutionary history of this sub-lineage on the continent. In this study, we used whole genome sequences of 781 L2 clinical strains from 14 geographical regions globally distributed to investigate the origins and onward spread of this lineage in Africa. Our results reveal multiple introductions of L2–Beijing into Africa linked to independent bacterial populations from East- and Southeast Asia. Bayesian analyses further indicate that these introductions occurred during the past 300 years, with most of these events pre-dating the antibiotic era. Hence, the success of L2–Beijing in Africa is most likely due to its hypervirulence and high transmissibility rather than drug resistance.en_ZA
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fevo.2019.00112/full
dc.description.versionPublisher's version
dc.format.extent12 pagesen_ZA
dc.identifier.citationRutaihwa, L. K. 2019. Multiple introductions of mycobacterium tuberculosis lineage 2–Beijing into Africa over centuries. Frontiers in Ecology and Evolution, 7:112, doi:10.3389/fevo.2019.00112
dc.identifier.issn2296-701X (online)
dc.identifier.otherdoi:10.3389/fevo.2019.00112
dc.identifier.urihttp://hdl.handle.net/10019.1/123357
dc.language.isoen_ZAen_ZA
dc.publisherFrontiers Mediaen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectTuberculosisen_ZA
dc.subjectMycobacterium tuberculosisen_ZA
dc.subjectNucleotide sequenceen_ZA
dc.subjectMultidrug-resistant tuberculosisen_ZA
dc.subjectGenomes -- Diversityen_ZA
dc.titleMultiple introductions of mycobacterium tuberculosis lineage 2–Beijing into Africa over centuriesen_ZA
dc.typeArticleen_ZA
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