Association between fluoroquinolone resistance and MRSA genotype in Alexandria, Egypt

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dc.contributor.authorAlseqely, Mustafaen_ZA
dc.contributor.authorNewton-Foot, Maeen_ZA
dc.contributor.authorKhalil, Amalen_ZA
dc.contributor.authorEl-Nakeeb, Mostafaen_ZA
dc.contributor.authorWhitelaw, Andrewen_ZA
dc.contributor.authorAbouelfetouh, Alaaen_ZA
dc.date.accessioned2023-04-03T13:11:04Zen_ZA
dc.date.available2023-04-03T13:11:04Zen_ZA
dc.date.issued2021-02-19en_ZA
dc.descriptionCITATION: Alseqely, M. et al. 2021. Association between fluoroquinolone resistance and MRSA genotype in Alexandria, Egypt. Scientific Reports, 11:4253, doi:10.1038/s41598-021-83578-2.en_ZA
dc.descriptionThe original publication is available at https://www.nature.comen_ZA
dc.description.abstractAntimicrobial stewardship isn’t strictly observed in most Egyptian hospitals, raising antibiotic resistance. Epidemiology of Egyptian MRSA isolates, or associations with resistance to other antibiotics remain largely unknown. We identified MRSA genotypes in Alexandria Main University Hospital (AMUH) and investigated rates of moxifloxacin resistance, an alternative MRSA treatment, among different genotypes. Antibiotic susceptibility of 72 MRSA clinical isolates collected in 2015 from AMUH was determined by disc diffusion and broth microdilution. spa- and Staphylococcal Cassette Chromosome mec (SCCmec) typing were performed; with multi-locus sequence typing conducted on isolates representing major genotypes. Resistance to moxifloxacin, levofloxacin and ciprofloxacin were 69%, 78% and 96%, respectively. spa type t037 (57%) was commonest, followed by t127 (12.5%), t267 (8%) and t688 (6%). SCCmec III predominated (57%), all of these were moxifloxacin resistant and 97.6% t037 (ST241). SCCmec IV, IV E and V represented 15%, 7% and 11% of the isolates, respectively, 79% of these were moxifloxacin susceptible and of different spa types. t127 (ST-1) was associated with SCCmec V in 56% of the isolates, mostly moxifloxacin susceptible. Moxifloxacin resistance was high, most resistant isolates belonged to t037 and SCCmec III, suggesting local dissemination and antibiotic pressure. We recommend caution in treating MRSA infections with moxifloxacin.en_ZA
dc.description.urihttps://www.nature.com/articles/s41598-021-83578-2en_ZA
dc.description.versionPublisher's versionen_ZA
dc.format.extent9 pagesen_ZA
dc.identifier.citationAlseqely, M. et al. 2021. Association between fluoroquinolone resistance and MRSA genotype in Alexandria, Egypt. Scientific Reports, 11:4253, doi:10.1038/s41598-021-83578-2.en_ZA
dc.identifier.issn2045-2322 (online)en_ZA
dc.identifier.otherdoi:10.1038/s41598-021-83578-2en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/126762en_ZA
dc.language.isoen_ZAen_ZA
dc.publisherNatureen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectFluoroquinolonesen_ZA
dc.subjectAnti-infective agentsen_ZA
dc.subjectMethicillin resistanceen_ZA
dc.subjectHospitals -- Egypten_ZA
dc.titleAssociation between fluoroquinolone resistance and MRSA genotype in Alexandria, Egypten_ZA
dc.typeArticleen_ZA
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