Appetitive and reactive aggression are differentially associated with the STin2 genetic variant in the serotonin transporter gene

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dc.contributor.authorHemmings, Sian M. J.en_ZA
dc.contributor.authorXulu, Khetheloen_ZA
dc.contributor.authorSommer, Jessicaen_ZA
dc.contributor.authorHinsberger, Martinaen_ZA
dc.contributor.authorMalan-Muller, Stefanieen_ZA
dc.contributor.authorTromp, Gerarden_ZA
dc.contributor.authorElbert, Thomasen_ZA
dc.contributor.authorWeierstall, Rolanden_ZA
dc.contributor.authorSeedat, Sorayaen_ZA
dc.date.accessioned2019-07-22T06:49:41Z
dc.date.available2019-07-22T06:49:41Z
dc.date.issued2018-04
dc.descriptionCITATION: Hemmings, S. M. J., et al. 2018. Appetitive and reactive aggression are differentially associated with the STin2 genetic variant in the serotonin transporter gene. Scientific Reports, 8:6714, doi:10.1038/s41598-018-25066-8.
dc.descriptionThe original publication is available at https://jefjournal.org.za
dc.descriptionPublication of this article was funded by the Stellenbosch University Open Access Fund
dc.description.abstractAppetitive aggression is a sub-category of instrumental aggression, characterised by the primary intrinsic enjoyment of aggressive activity. Aggression is heritable, and serotonergic and monoaminergic neurotransmitter systems have been found to contribute to the underlying molecular mechanisms. The aim of this study was to investigate the role that genetic variants in the serotonin transporter (SLC6A4) and monoamine oxidase A (MAOA) genes play in the aetiology of appetitive aggression in South African Xhosa males (n = 290). SLC6A4 5-HTTLPR, rs25531, and STin2 variants, as well as MAOA-uVNTR were investigated for their association with levels of appetitive aggression using Poisson regression analysis. The STin2 VNTR12 allele was found to be associated with increased levels of appetitive aggression (p = 0.003), but with decreased levels of reactive aggression (p = 7 × 10−5). This study is the first to investigate genetic underpinnings of appetitive aggression in a South African population, with preliminary evidence suggesting that SCL6A4 STin2 variants play a role in its aetiology, and may also be important in differentiating between appetitive and reactive aggression. Although the results require replication, they shed some preliminary light on the molecular dichotomy that may underlie the two forms of aggression.en_ZA
dc.description.urihttps://www.nature.com/articles/s41598-018-25066-8
dc.description.versionPublisher's version
dc.format.extent9 pages
dc.identifier.citationHemmings, S. M. J., et al. 2018. Appetitive and reactive aggression are differentially associated with the STin2 genetic variant in the serotonin transporter gene. Scientific Reports, 8:6714, doi:10.1038/s41598-018-25066-8
dc.identifier.issn2045-2322 (print)
dc.identifier.otherdoi:10.1038/s41598-018-25066-8
dc.identifier.urihttp://hdl.handle.net/10019.1/106318
dc.language.isoen_ZAen_ZA
dc.publisherNature Research (part of Springer Nature)
dc.rights.holderAuthors retain copyright
dc.subjectSerotonin Transporter Geneen_ZA
dc.subjectAggressiveness -- Genetic aspects -- South Africaen_ZA
dc.titleAppetitive and reactive aggression are differentially associated with the STin2 genetic variant in the serotonin transporter geneen_ZA
dc.typeArticleen_ZA
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