The diagnostic yield and safety of ultrasound-assisted transthoracic fine-needle aspiration of drowned lung
dc.contributor.author | Koegelenberg C.F.N. | |
dc.contributor.author | Bolliger C.T. | |
dc.contributor.author | Irusen E.M. | |
dc.contributor.author | Wright C.A. | |
dc.contributor.author | Louw M. | |
dc.contributor.author | Schubert P.T. | |
dc.contributor.author | Diacon A.H. | |
dc.date.accessioned | 2011-05-15T16:17:49Z | |
dc.date.available | 2011-05-15T16:17:49Z | |
dc.date.issued | 2011 | |
dc.description.abstract | Background: Proximal lung tumors, though not discernable by means of transthoracic ultrasound (US), may cause varying degrees of pulmonary collapse and postobstructive pneumonitis which may give rise to a 'drowned lung' appearance on chest computed tomography (CT) and US. The diagnostic yield for malignancy of US-assisted transthoracic fine-needle aspiration (FNA) of these areas of drowned lung is unknown. Objectives: We aimed to explore the feasibility of US-assisted FNA in this setting by prospectively investigating its diagnostic yield and safety. Methods: We enrolled 31 patients (aged 59.4 ± 9.7 years, 17 males) with central tumors and secondary drowned lung on CT scan. A respiratory physician performed transthoracic US to identify the target drowned lung tissue. Three US-assisted superficial FNA passes (≤20 mm from the pleura) were followed by 3 deeper FNA passes (>20 mm) aimed in the direction of a visible or approximated central mass. Rapid on-site evaluation of specimens was used. Results: Superficial FNA was diagnostic in 11 patients (35.5%), whereas deeper FNA was diagnostic in 23 patients (74.2%, p = 0.002). Deeper FNA confirmed malignancy in all cases with diagnostic superficial FNA. We observed no pneumothoraces or major hemorrhage. All patients were ultimately diagnosed with malignancy (bronchogenic carcinoma, n = 30; lymphoma, n = 1). Conclusions: US-assisted FNA of drowned lung has an acceptable diagnostic yield and is safe. Copyright © 2010 S. Karger AG, Basel. | |
dc.description.version | Article | |
dc.identifier.citation | Respiration | |
dc.identifier.citation | 81 | |
dc.identifier.citation | 1 | |
dc.identifier.issn | 00257931 | |
dc.identifier.other | 10.1159/000319576 | |
dc.identifier.uri | http://hdl.handle.net/10019.1/14385 | |
dc.subject | adult | |
dc.subject | article | |
dc.subject | cancer diagnosis | |
dc.subject | clinical trial | |
dc.subject | computer assisted tomography | |
dc.subject | diagnostic test accuracy study | |
dc.subject | diagnostic value | |
dc.subject | drowned lung | |
dc.subject | echography | |
dc.subject | feasibility study | |
dc.subject | female | |
dc.subject | human | |
dc.subject | human tissue | |
dc.subject | large cell carcinoma | |
dc.subject | lung adenocarcinoma | |
dc.subject | lung carcinoma | |
dc.subject | lung disease | |
dc.subject | lung hemorrhage | |
dc.subject | lung small cell cancer | |
dc.subject | lung squamous cell carcinoma | |
dc.subject | major clinical study | |
dc.subject | male | |
dc.subject | nodular sclerosis Hodgkin lymphoma | |
dc.subject | patient safety | |
dc.subject | pleura | |
dc.subject | priority journal | |
dc.subject | prospective study | |
dc.subject | pulmonology | |
dc.subject | sensitivity and specificity | |
dc.subject | transthoracic aspiration | |
dc.subject | undifferentiated carcinoma | |
dc.title | The diagnostic yield and safety of ultrasound-assisted transthoracic fine-needle aspiration of drowned lung | |
dc.type | Article |