The diagnostic yield and safety of ultrasound-assisted transthoracic fine-needle aspiration of drowned lung

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dc.contributor.authorKoegelenberg C.F.N.
dc.contributor.authorBolliger C.T.
dc.contributor.authorIrusen E.M.
dc.contributor.authorWright C.A.
dc.contributor.authorLouw M.
dc.contributor.authorSchubert P.T.
dc.contributor.authorDiacon A.H.
dc.date.accessioned2011-05-15T16:17:49Z
dc.date.available2011-05-15T16:17:49Z
dc.date.issued2011
dc.description.abstractBackground: Proximal lung tumors, though not discernable by means of transthoracic ultrasound (US), may cause varying degrees of pulmonary collapse and postobstructive pneumonitis which may give rise to a 'drowned lung' appearance on chest computed tomography (CT) and US. The diagnostic yield for malignancy of US-assisted transthoracic fine-needle aspiration (FNA) of these areas of drowned lung is unknown. Objectives: We aimed to explore the feasibility of US-assisted FNA in this setting by prospectively investigating its diagnostic yield and safety. Methods: We enrolled 31 patients (aged 59.4 ± 9.7 years, 17 males) with central tumors and secondary drowned lung on CT scan. A respiratory physician performed transthoracic US to identify the target drowned lung tissue. Three US-assisted superficial FNA passes (≤20 mm from the pleura) were followed by 3 deeper FNA passes (>20 mm) aimed in the direction of a visible or approximated central mass. Rapid on-site evaluation of specimens was used. Results: Superficial FNA was diagnostic in 11 patients (35.5%), whereas deeper FNA was diagnostic in 23 patients (74.2%, p = 0.002). Deeper FNA confirmed malignancy in all cases with diagnostic superficial FNA. We observed no pneumothoraces or major hemorrhage. All patients were ultimately diagnosed with malignancy (bronchogenic carcinoma, n = 30; lymphoma, n = 1). Conclusions: US-assisted FNA of drowned lung has an acceptable diagnostic yield and is safe. Copyright © 2010 S. Karger AG, Basel.
dc.description.versionArticle
dc.identifier.citationRespiration
dc.identifier.citation81
dc.identifier.citation1
dc.identifier.issn00257931
dc.identifier.other10.1159/000319576
dc.identifier.urihttp://hdl.handle.net/10019.1/14385
dc.subjectadult
dc.subjectarticle
dc.subjectcancer diagnosis
dc.subjectclinical trial
dc.subjectcomputer assisted tomography
dc.subjectdiagnostic test accuracy study
dc.subjectdiagnostic value
dc.subjectdrowned lung
dc.subjectechography
dc.subjectfeasibility study
dc.subjectfemale
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectlarge cell carcinoma
dc.subjectlung adenocarcinoma
dc.subjectlung carcinoma
dc.subjectlung disease
dc.subjectlung hemorrhage
dc.subjectlung small cell cancer
dc.subjectlung squamous cell carcinoma
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectnodular sclerosis Hodgkin lymphoma
dc.subjectpatient safety
dc.subjectpleura
dc.subjectpriority journal
dc.subjectprospective study
dc.subjectpulmonology
dc.subjectsensitivity and specificity
dc.subjecttransthoracic aspiration
dc.subjectundifferentiated carcinoma
dc.titleThe diagnostic yield and safety of ultrasound-assisted transthoracic fine-needle aspiration of drowned lung
dc.typeArticle
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