Are neuroendocrine cells of practical value as an independent prognostic parameter in prostate cancer?

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dc.contributor.authorAllen F.J.
dc.contributor.authorVan Velden D.J.J.
dc.contributor.authorHeyns C.F.
dc.date.accessioned2011-05-15T16:15:50Z
dc.date.available2011-05-15T16:15:50Z
dc.date.issued1995
dc.description.abstractObjective - To assess whether the presence of neuroendocrine (NE) cells is of value as an independent indicator of poor prognosis in patients with prostate carcinoma. Patients and methods - A series of 160 consecutive patients with prostate carcinoma was studied retrospectively. In 120 there was sufficient tissue for review and to perform immunoperoxidase stains for neuron specific enolase (NSE) and chromogranin A (CGA). All patients had a potential follow-up of at least 5 years. Results - Five-year survival was poorer for patients with a high tumour grade and stage at presentation compared to those with a lower grade and stage. NE cells were more common in higher grade and stage disease, but S-year survival did not differ significantly between patients with NE cell positive and negative tumours. Conclusion - NE cells are of no practical value as an independent prognostic indicator in patients with prostatic adenocarcinoma.
dc.description.versionArticle
dc.identifier.citationBritish Journal of Urology
dc.identifier.citation75
dc.identifier.citation6
dc.identifier.issn00071331
dc.identifier.urihttp://hdl.handle.net/10019.1/13509
dc.subjectchromogranin
dc.subjectneuron specific enolase
dc.subjectarticle
dc.subjectcancer grading
dc.subjectcancer staging
dc.subjectfollow up
dc.subjecthuman
dc.subjectimmunoperoxidase staining
dc.subjectmajor clinical study
dc.subjectneuroendocrine disease
dc.subjectpriority journal
dc.subjectprognosis
dc.subjectprostate cancer
dc.subjectretrospective study
dc.subjectsurvival
dc.subjectAdenocarcinoma
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectFollow-Up Studies
dc.subjectHuman
dc.subjectMale
dc.subjectMiddle Age
dc.subjectNeurosecretory Systems
dc.subjectPrognosis
dc.subjectProstatic Neoplasms
dc.subjectRetrospective Studies
dc.subjectSurvival Analysis
dc.titleAre neuroendocrine cells of practical value as an independent prognostic parameter in prostate cancer?
dc.typeArticle
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