Nutritional supplements for people being treated for active tuberculosis : a technical summary

dc.contributor.authorGrobler, L.en_ZA
dc.contributor.authorDurao, Solangeen_ZA
dc.contributor.authorVan der Merwe, S. M.en_ZA
dc.contributor.authorWessels, J.en_ZA
dc.contributor.authorNaude, Celeste E.en_ZA
dc.date.accessioned2019-11-19T10:21:09Z
dc.date.available2019-11-19T10:21:09Z
dc.date.issued2018
dc.descriptionCITATION: Grobler, L. et al. 2018. Nutritional supplements for people being treated for active tuberculosis : a technical summary. South African Medical Journal, 108(1):16-18, doi:10.7196/SAMJ.2017.v108i1.12839.
dc.descriptionThe original publication is available at http://www.samj.org.za
dc.description.abstractTuberculosis and nutrition are intrinsically linked in a complex relationship. Altered metabolism and loss of appetite associated with tuberculosis may result in undernutrition, which in turn may worsen the disease or delay recovery. We highlight an updated Cochrane review assessing the effects of oral nutritional supplements in people with active tuberculosis who are receiving antituberculosis drug therapy. The review authors conducted a comprehensive search (February 2016) for all randomised controlled trials comparing any oral nutritional supplement, given for at least 4 weeks, with no nutritional intervention, placebo or dietary advice only in people receiving antituberculosis treatment. Of the 35 trials (N=8 283 participants) included, seven assessed the provision of free food or high-energy supplements, six assessed multi-micronutrient supplementation, and 21 assessed single- or dual-micronutrient supplementation. There is currently insufficient evidence to indicate whether routinely providing free food or high-energy supplements improves antituberculosis treatment outcomes (i.e. reduced death and increased cure rates at 6 and 12 months), but it probably improves weight gain in some settings. Plasma levels of zinc, vitamin D, vitamin E and selenium probably improve with supplementation, but currently no reliable evidence demonstrates that routine supplementation with multi-, single or dual micronutrients above the recommended daily intake has clinical benefits (i.e. reduced death, increased cure rate at 6 and 12 months, improved nutritional status) in patients receiving antituberculosis treatment. In South Africa, most provinces implement a supplementation protocol based on nutritional assessment and classification of individuals rather than on disease diagnosis or treatment status.en_ZA
dc.description.sponsorshipEffective Health Care Research Consortium (UK)
dc.description.urihttp://www.samj.org.za/index.php/samj/article/view/12176
dc.description.versionPublisher's version
dc.format.extent3 pages
dc.identifier.citationGrobler, L. et al. 2018. Nutritional supplements for people being treated for active tuberculosis : a technical summary. South African Medical Journal, 108(1):16-18, doi:10.7196/SAMJ.2017.v108i1.12839.
dc.identifier.issn2078-5135 (online)
dc.identifier.issn0256-9574 (print)
dc.identifier.otherdoi:10.7196/SAMJ.2017.v108i1.12839
dc.identifier.urihttp://hdl.handle.net/10019.1/106855
dc.language.isoen_ZAen_ZA
dc.publisherHealth & Medical Publishing Group
dc.rights.holderAuthors retain copyright
dc.subjectTuberculosis -- Patients -- Nutritionen_ZA
dc.subjectDietary supplementsen_ZA
dc.subjectCochrane reviewsen_ZA
dc.subjectEvidence-based medicineen_ZA
dc.titleNutritional supplements for people being treated for active tuberculosis : a technical summaryen_ZA
dc.typeArticleen_ZA
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