Implementation of tuberculosis intensive case finding, isoniazid preventive therapy, and infection control ("Three I's") and HIV-tuberculosis service integration in lower income countries

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dc.contributor.authorCharles, M. Katherineen_ZA
dc.contributor.authorLindegren, Mary Louen_ZA
dc.contributor.authorWester, C. Williamen_ZA
dc.contributor.authorBlevins, Meridithen_ZA
dc.contributor.authorSterling, Timothy R.en_ZA
dc.contributor.authorDung, Nguyen Thien_ZA
dc.contributor.authorDusingize, Jean Claudeen_ZA
dc.contributor.authorAvit-Edi, Divineen_ZA
dc.contributor.authorDurier, Nicolasen_ZA
dc.contributor.authorCastelnuovo, Barbaraen_ZA
dc.contributor.authorNakigozi, Gertrudeen_ZA
dc.contributor.authorCortes, Claudia P.en_ZA
dc.contributor.authorBallif, Marieen_ZA
dc.contributor.authorFenner, Lukasen_ZA
dc.contributor.authorInternational epidemiology Databases to Evaluate AIDS (IeDEA) Collaborationen_ZA
dc.date.accessioned2017-10-02T13:32:21Z
dc.date.available2017-10-02T13:32:21Z
dc.date.issued2016
dc.descriptionCITATION: Charles, M. K., et al. 2016. Implementation of tuberculosis intensive case finding, isoniazid preventive therapy, and infection control ("Three I's") and HIV-tuberculosis service integration in lower income countries. PLoS ONE, 11(4):e0153243, doi:10.1371/journal.pone.0153243.
dc.descriptionThe original publication is available at http://journals.plos.org/plosone
dc.description.abstractSetting: World Health Organization advocates for integration of HIV-tuberculosis (TB) services and recommends intensive case finding (ICF), isoniazid preventive therapy (IPT), and infection control (“Three I’s”) for TB prevention and control among persons living with HIV. Objective: To assess the implementation of the “Three I’s” of TB-control at HIV treatment sites in lower income countries. Design: Survey conducted between March-July, 2012 at 47 sites in 26 countries: 6 (13%) Asia Pacific, 7 (15%), Caribbean, Central and South America, 5 (10%) Central Africa, 8 (17%) East Africa, 14 (30%) Southern Africa, and 7 (15%) West Africa. Results: ICF using symptom-based screening was performed at 38% of sites; 45% of sites used symptom-screening plus additional diagnostics. IPT at enrollment or ART initiation was implemented in only 17% of sites, with 9% of sites providing IPT to tuberculin-skin-test positive patients. Infection control measures varied: 62% of sites separated smear-positive patients, and healthcare workers used masks at 57% of sites. Only 12 (26%) sites integrated HIV-TB services. Integration was not associated with implementation of TB prevention measures except for IPT provision at enrollment (42% integrated vs. 9% non-integrated; p = 0.03). Conclusions: Implementation of TB screening, IPT provision, and infection control measures was low and variable across regional HIV treatment sites, regardless of integration status.en_ZA
dc.description.urihttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153243
dc.description.versionPublisher's version
dc.format.extent12 pages
dc.identifier.citationCharles, M. K., et al. 2016. Implementation of tuberculosis intensive case finding, isoniazid preventive therapy, and infection control ("Three I's") and HIV-tuberculosis service integration in lower income countries. PLoS ONE, 11(4):e0153243, doi:10.1371/journal.pone.0153243
dc.identifier.issn1932-6203 (online)
dc.identifier.otherdoi:10.1371/journal.pone.0153243
dc.identifier.urihttp://hdl.handle.net/10019.1/102292
dc.language.isoen_ZAen_ZA
dc.publisherPublic Library of Science
dc.rights.holderAuthors retain copyright
dc.subjectTuberculosis -- Diagnosis -- Developing countriesen_ZA
dc.subjectTuberculosis -- Preventionen_ZA
dc.subjectDeveloping countries -- Health and hygieneen_ZA
dc.subjectIsoniaziden_ZA
dc.subjectAntitubercular agentsen_ZA
dc.subjectInfection -- Preventionen_ZA
dc.subjectHIV infections -- Preventionen_ZA
dc.titleImplementation of tuberculosis intensive case finding, isoniazid preventive therapy, and infection control ("Three I's") and HIV-tuberculosis service integration in lower income countriesen_ZA
dc.typeArticleen_ZA
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